Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

Bjarne Linde Nørgaard; Jonathon Leipsic; Bon-Kwon Koo; Christopher K Zarins; Jesper Møller Jensen; Niels Peter Sand; Charles A Taylor

doi:10.1007/s12410-015-9366-5

Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

Bjarne Linde Nørgaard, Jonathon Leipsic, Bon-Kwon Koo, Christopher K Zarins, Jesper Møller Jensen, Niels Peter Sand, Charles A Taylor

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.

Originalsprog	Engelsk
Artikelnummer	2
Tidsskrift	Current cardiovascular imaging reports
Vol/bind	9
Nummer	1
Sider (fra-til)	2
Antal sider	12
ISSN	1941-9066
DOI	https://doi.org/10.1007/s12410-015-9366-5
Status	Udgivet - 5 mar. 2016

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title = "Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress",

abstract = "Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.",

keywords = "Atherosclerosis, Axial plaque stress, Computational fluid dynamics, Coronary artery disease, Coronary computed tomography angiography, Coronary plaque, Fractional flow reserve, Invasive coronary angiography, Myocardial ischemia, Noninvasive cardiac imaging, Noninvasive diagnostic testing, Prognosis, Wall shear stress",

author = "N{\o}rgaard, {Bjarne Linde} and Jonathon Leipsic and Bon-Kwon Koo and Zarins, {Christopher K} and Jensen, {Jesper M{\o}ller} and Sand, {Niels Peter} and Taylor, {Charles A}",

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doi = "10.1007/s12410-015-9366-5",

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Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress. / Nørgaard, Bjarne Linde; Leipsic, Jonathon; Koo, Bon-Kwon et al.
I: Current cardiovascular imaging reports, Bind 9, Nr. 1, 2, 05.03.2016, s. 2.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

AU - Nørgaard, Bjarne Linde

AU - Leipsic, Jonathon

AU - Koo, Bon-Kwon

AU - Zarins, Christopher K

AU - Jensen, Jesper Møller

AU - Sand, Niels Peter

AU - Taylor, Charles A

PY - 2016/3/5

Y1 - 2016/3/5

N2 - Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.

AB - Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.

KW - Atherosclerosis

KW - Axial plaque stress

KW - Computational fluid dynamics

KW - Coronary artery disease

KW - Coronary computed tomography angiography

KW - Coronary plaque

KW - Fractional flow reserve

KW - Invasive coronary angiography

KW - Myocardial ischemia

KW - Noninvasive cardiac imaging

KW - Noninvasive diagnostic testing

KW - Prognosis

KW - Wall shear stress

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U2 - 10.1007/s12410-015-9366-5

DO - 10.1007/s12410-015-9366-5

M3 - Journal article

C2 - 26941886

SN - 1941-9066

VL - 9

SP - 2

JO - Current cardiovascular imaging reports

JF - Current cardiovascular imaging reports

IS - 1

M1 - 2

ER -

Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

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