Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis

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Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis. / Kyvsgaard, Nini; Thastum, Mikael; Mikkelsen, Torben Stamm; Christensen, Anne Estmann; Herlin, Troels.

I: Rheumatology International, Bind 40, Nr. 4, 04.2020, s. 591-598.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{70d1aba852ba4670ab9764c29b2c2af7,
title = "Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis",
abstract = "The aim of this study is to investigate whether methotrexate-induced nausea is associated with anxiety or the use of coping strategies in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). This is an observational study of children diagnosed with JIA (ILAR criteria), treated with MTX and aged 9 years or above. MTX-induced nausea was determined by the children's completion of a nausea diary and the parents' completion of the Methotrexate Intolerance Severity Score (MISS). Anxiety was assessed by the Beck Youth Inventories-Anxiety Inventory (BYI-A) and coping strategies were evaluated by an adapted Nausea Coping Questionnaire. Enrolled were 121 children (82 girls: 39 boys) with a median age (IQR) of 13.3 (11.3-15.1) years. The median MTX-dose (IQR) was 9.7 (9.0-10.9) mg/m2/week. The median treatment duration (IQR) was 340 (142-766) days. The MISS was completed for 120 children; 77 children completed the nausea diary for at least 7 days. MTX-induced nausea was present in 61% (73/120) of the children according to the MISS and in 73% (56/77) of the children according to the nausea diary. MTX-induced nausea was associated with a more frequent use of the coping strategy internalizing/catastrophizing (MISS, p = 0.012; diary, p < 0.0001) and higher BYI-A raw scores (diary, p = 0.016). MTX-induced nausea was associated with anxiety and the use of coping strategies in children with JIA. These psychological factors may be part of the mechanism behind the inter-individual variation in the level of nausea to MTX treatment.",
keywords = "Anxiety, Coping strategies, Juvenile idiopathic arthritis, Methotrexate, Nausea, RHEUMATOID-ARTHRITIS, CHEMOTHERAPY-INDUCED NAUSEA, VALIDATION, RELIABILITY, CHILDHOOD, CHILDREN, PAIN, PEDIATRIC CANCER-PATIENTS, ADOLESCENTS, QUESTIONNAIRE",
author = "Nini Kyvsgaard and Mikael Thastum and Mikkelsen, {Torben Stamm} and Christensen, {Anne Estmann} and Troels Herlin",
year = "2020",
month = apr,
doi = "10.1007/s00296-020-04520-9",
language = "English",
volume = "40",
pages = "591--598",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis

AU - Kyvsgaard, Nini

AU - Thastum, Mikael

AU - Mikkelsen, Torben Stamm

AU - Christensen, Anne Estmann

AU - Herlin, Troels

PY - 2020/4

Y1 - 2020/4

N2 - The aim of this study is to investigate whether methotrexate-induced nausea is associated with anxiety or the use of coping strategies in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). This is an observational study of children diagnosed with JIA (ILAR criteria), treated with MTX and aged 9 years or above. MTX-induced nausea was determined by the children's completion of a nausea diary and the parents' completion of the Methotrexate Intolerance Severity Score (MISS). Anxiety was assessed by the Beck Youth Inventories-Anxiety Inventory (BYI-A) and coping strategies were evaluated by an adapted Nausea Coping Questionnaire. Enrolled were 121 children (82 girls: 39 boys) with a median age (IQR) of 13.3 (11.3-15.1) years. The median MTX-dose (IQR) was 9.7 (9.0-10.9) mg/m2/week. The median treatment duration (IQR) was 340 (142-766) days. The MISS was completed for 120 children; 77 children completed the nausea diary for at least 7 days. MTX-induced nausea was present in 61% (73/120) of the children according to the MISS and in 73% (56/77) of the children according to the nausea diary. MTX-induced nausea was associated with a more frequent use of the coping strategy internalizing/catastrophizing (MISS, p = 0.012; diary, p < 0.0001) and higher BYI-A raw scores (diary, p = 0.016). MTX-induced nausea was associated with anxiety and the use of coping strategies in children with JIA. These psychological factors may be part of the mechanism behind the inter-individual variation in the level of nausea to MTX treatment.

AB - The aim of this study is to investigate whether methotrexate-induced nausea is associated with anxiety or the use of coping strategies in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). This is an observational study of children diagnosed with JIA (ILAR criteria), treated with MTX and aged 9 years or above. MTX-induced nausea was determined by the children's completion of a nausea diary and the parents' completion of the Methotrexate Intolerance Severity Score (MISS). Anxiety was assessed by the Beck Youth Inventories-Anxiety Inventory (BYI-A) and coping strategies were evaluated by an adapted Nausea Coping Questionnaire. Enrolled were 121 children (82 girls: 39 boys) with a median age (IQR) of 13.3 (11.3-15.1) years. The median MTX-dose (IQR) was 9.7 (9.0-10.9) mg/m2/week. The median treatment duration (IQR) was 340 (142-766) days. The MISS was completed for 120 children; 77 children completed the nausea diary for at least 7 days. MTX-induced nausea was present in 61% (73/120) of the children according to the MISS and in 73% (56/77) of the children according to the nausea diary. MTX-induced nausea was associated with a more frequent use of the coping strategy internalizing/catastrophizing (MISS, p = 0.012; diary, p < 0.0001) and higher BYI-A raw scores (diary, p = 0.016). MTX-induced nausea was associated with anxiety and the use of coping strategies in children with JIA. These psychological factors may be part of the mechanism behind the inter-individual variation in the level of nausea to MTX treatment.

KW - Anxiety

KW - Coping strategies

KW - Juvenile idiopathic arthritis

KW - Methotrexate

KW - Nausea

KW - RHEUMATOID-ARTHRITIS

KW - CHEMOTHERAPY-INDUCED NAUSEA

KW - VALIDATION

KW - RELIABILITY

KW - CHILDHOOD

KW - CHILDREN

KW - PAIN

KW - PEDIATRIC CANCER-PATIENTS

KW - ADOLESCENTS

KW - QUESTIONNAIRE

U2 - 10.1007/s00296-020-04520-9

DO - 10.1007/s00296-020-04520-9

M3 - Journal article

C2 - 31996982

VL - 40

SP - 591

EP - 598

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 4

ER -