Controlling nuclear RNA levels

Manfred Schmid, Torben Heick Jensen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

103 Citationer (Scopus)

Abstract

RNA turnover is an integral part of cellular RNA homeostasis and gene expression regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of study, we discuss here the less appreciated role of nuclear RNA decay systems in controlling RNA polymerase II (RNAPII)-derived transcripts. Historically, nuclear RNA degradation was found to be essential for the functionalization of transcripts through their proper maturation. Later, it was discovered to also be an important caretaker of nuclear hygiene by removing aberrant and unwanted transcripts. Recent years have now seen a set of new protein complexes handling a variety of new substrates, revealing functions beyond RNA processing and the decay of non-functional transcripts. This includes an active contribution of nuclear RNA metabolism to the overall cellular control of RNA levels, with mechanistic implications during cellular transitions.

OriginalsprogEngelsk
TidsskriftNature Reviews. Genetics
Vol/bind19
Nummer8
Sider (fra-til)518-529
Antal sider12
ISSN1471-0056
DOI
StatusUdgivet - 10 aug. 2018

Fingeraftryk

Dyk ned i forskningsemnerne om 'Controlling nuclear RNA levels'. Sammen danner de et unikt fingeraftryk.

Citationsformater