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Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

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  • V. E. Gruzdev, University of Missouri-Columbia
  • ,
  • D. Korkin, Worcester Polytechnic Institute
  • ,
  • B. P. Mooney, University of Missouri-Columbia
  • ,
  • J. F. Havelund, Dept. of Biochemistry and Molecular Biology, University of Southern Denmark
  • ,
  • I. M. Møller
  • J. J. Thelen, University of Missouri-Columbia

Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

OriginalsprogEngelsk
TitelProceedings - International Conference Laser Optics 2018, ICLO 2018
Antal sider1
ForlagIEEE
Udgivelsesår13 aug. 2018
Artikelnummer8435786
ISBN (trykt)9781538636121
DOI
StatusUdgivet - 13 aug. 2018
Begivenhed2018 International Conference Laser Optics, ICLO 2018 - St. Petersburg, Rusland
Varighed: 4 jun. 20188 jun. 2018

Konference

Konference2018 International Conference Laser Optics, ICLO 2018
LandRusland
BySt. Petersburg
Periode04/06/201808/06/2018

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