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Control of non-productive RNA polymerase II transcription via its early termination in metazoans

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Transcription establishes the universal first step of gene expression where RNA is produced by a DNA-dependent RNA polymerase. The most versatile of eukaryotic RNA polymerases, RNA polymerase II (Pol II), transcribes a broad range of DNA including protein-coding and a variety of non-coding transcription units. Although Pol II can be configured as a durable enzyme capable of transcribing hundreds of kilobases, there is reliable evidence of widespread abortive Pol II transcription termination shortly after initiation, which is often followed by rapid degradation of the associated RNA. The molecular details underlying this phenomenon are still vague but likely reflect the action of quality control mechanisms on the early Pol II complex. Here, we summarize current knowledge of how and when such promoter-proximal quality control is asserted on metazoan Pol II.

OriginalsprogEngelsk
TidsskriftBiochemical Society Transactions
Vol/bind50
Nummer1
Sider (fra-til)283-295
Antal sider13
ISSN0300-5127
DOI
StatusUdgivet - feb. 2022

Bibliografisk note

Funding Information:
Work in the T.H.J. laboratory on this topic is supported by the Lundbeck Foundation [R1982015-172] and the Novo Nordisk Foundation [NNF18OC0033380]. J.O.R. is additionally supported by a Lundbeck Foundation Postdoc grant [R303-2018-3134].

Publisher Copyright:
© 2022 The Author(s).

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