Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts

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Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts. / Joyce, William; Axelsson, Michael; Wang, Tobias.

I: The Journal of Experimental Biology, Bind 222, 2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Joyce, William ; Axelsson, Michael ; Wang, Tobias. / Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts. I: The Journal of Experimental Biology. 2019 ; Bind 222.

Bibtex

@article{7b7325754bf94fd6be5db8d9c936ce54,
title = "Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts",
abstract = "Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtles more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here, we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trachemys scripta elegans), we demonstrated that activation of smooth muscle contraction with histamine (100 nmol kg-1 bolus injected into perfusate) reduced cardiac output by decreasing stroke volume (>50{\%} decrease in both parameters). Conversely, inhibition of smooth muscle contraction with wortmannin (10 µmol l-1 perfusion) approximately doubled baseline stroke volume and cardiac output. We suggest that atrial smooth muscle provides a unique mechanism to control cardiac filling that could be involved in the regulation of stroke volume during diving.",
keywords = "Cardiac filling, Diving, Stroke volume, Tonus waves",
author = "William Joyce and Michael Axelsson and Tobias Wang",
year = "2019",
doi = "10.1242/jeb.199828",
language = "English",
volume = "222",
journal = "BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY",
issn = "0022-0949",
publisher = "The/Company of Biologists Ltd.",

}

RIS

TY - JOUR

T1 - Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts

AU - Joyce, William

AU - Axelsson, Michael

AU - Wang, Tobias

PY - 2019

Y1 - 2019

N2 - Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtles more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here, we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trachemys scripta elegans), we demonstrated that activation of smooth muscle contraction with histamine (100 nmol kg-1 bolus injected into perfusate) reduced cardiac output by decreasing stroke volume (>50% decrease in both parameters). Conversely, inhibition of smooth muscle contraction with wortmannin (10 µmol l-1 perfusion) approximately doubled baseline stroke volume and cardiac output. We suggest that atrial smooth muscle provides a unique mechanism to control cardiac filling that could be involved in the regulation of stroke volume during diving.

AB - Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtles more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here, we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trachemys scripta elegans), we demonstrated that activation of smooth muscle contraction with histamine (100 nmol kg-1 bolus injected into perfusate) reduced cardiac output by decreasing stroke volume (>50% decrease in both parameters). Conversely, inhibition of smooth muscle contraction with wortmannin (10 µmol l-1 perfusion) approximately doubled baseline stroke volume and cardiac output. We suggest that atrial smooth muscle provides a unique mechanism to control cardiac filling that could be involved in the regulation of stroke volume during diving.

KW - Cardiac filling

KW - Diving

KW - Stroke volume

KW - Tonus waves

UR - http://www.scopus.com/inward/record.url?scp=85063618841&partnerID=8YFLogxK

U2 - 10.1242/jeb.199828

DO - 10.1242/jeb.199828

M3 - Journal article

VL - 222

JO - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

JF - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

SN - 0022-0949

ER -