Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up

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Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 ± 6.5 years, diabetes duration 16.1 ± 9.7 years, body mass index (BMI) 34.7 ± 3.9 kg/m2) partook in the study. Mean duration of CPAP treatment was 10.5 ± 1.5 months. Baseline cfPWV was 10.7 m/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV:-0.12 m/s, 95% confidence interval (CI):-0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 mm Hg, change in BP: 1.6 mm Hg, 95% CI:-2.3, 5.5. Conclusions: We found no effect of 9-12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.

OriginalsprogEngelsk
TidsskriftJournal of Endocrinology and Metabolism
Vol/bind11
Nummer5
Sider (fra-til)134-139
Antal sider6
ISSN1923-2861
DOI
StatusUdgivet - okt. 2021

Bibliografisk note

Funding Information:
This study is supported financially by: University of Aarhus, Regional Hospital Silkeborg, the Health Research Fund of the Central Denmark Region, the Danish Diabetes Academy supported by the Novo Nordisk Foundation, Toyota-Fonden, Denmark and Regional Hospital Central Jutland Research Fund.

Publisher Copyright:
© The authors | Journal compilation © J Endocrinol Metab and Elmer Press Inc™ | www.jofem.org.

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