Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Reynalda Cordova, Medical University Vienna, Vienna
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  • Nathalie Kliemann, Nutrition and Metabolism Branch
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  • Inge Huybrechts, Nutrition and Metabolism Branch
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  • Fernanda Rauber, São Paulo State University, São Paulo, Brazil
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  • Eszter P Vamos, Imperial Coll London, Imperial College London, UKDRI
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  • Renata Bertazzi Levy, São Paulo State University, São Paulo, Brazil
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  • Karl-Heinz Wagner, Medical University Vienna, Vienna
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  • Vivian Viallon, Nutrition and Metabolism Branch
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  • Corinne Casagrande, Nutrition and Metabolism Branch
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  • Geneviève Nicolas, Nutrition and Metabolism Branch
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  • Christina C Dahm
  • Jie Zhang
  • Jytte Halkjær, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
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  • Anne Tjønneland, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; i-PSYCH initiative for Integrative Psychiatric Research, Lundbeck Foundation, Copenhagen.
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  • Marie-Christine Boutron-Ruault, French National Institute for Health and Medical Research (INSERM)
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  • Francesca Romana Mancini, French National Institute for Health and Medical Research (INSERM)
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  • Nasser Laouali, French National Institute for Health and Medical Research (INSERM)
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  • Verena Katzke, German Cancer Research Center (DKFZ)
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  • Bernard Srour, German Cancer Research Center (DKFZ)
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  • Franziska Jannasch, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
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  • Matthias B Schulze, Univ Potsdam, University of Potsdam, Potsdam Res Inst Multilingualism
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  • Giovanna Masala, Institute for Cancer Research
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  • Sara Grioni, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milano, Italy.
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  • Salvatore Panico, Dipartimento die Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
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  • Yvonne T van der Schouw, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr
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  • Jeroen W G Derksen, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr
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  • Charlotta Rylander, UiT Arctic Univ Norway, UiT The Arctic University of Tromso, Inst Arctic & Marine Biol
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  • Guri Skeie, UiT Arctic Univ Norway, UiT The Arctic University of Tromso, Inst Arctic & Marine Biol
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  • Paula Jakszyn, University Ramon Llull
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  • Miguel Rodriguez-Barranco, Escuela Andaluza de Salud Pública (EASP), Granada
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  • José María Huerta, Department of Epidemiology Research & Department of Infectious Disease Epidemiology and Prevention
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  • Aurelio Barricarte, Navarra Public Health Institute
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  • Lousie Brunkwall, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden.
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  • Stina Ramne, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden.
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  • Stina Bodén, University of Umeå, Umeå, Sweden.
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  • Aurora Perez-Cornago, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Alicia K Heath, Imperial Coll London, Imperial College London, UKDRI
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  • Paolo Vineis, Imperial Coll London, Imperial College London, UKDRI
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  • Elisabete Weiderpass, Nutrition and Metabolism Branch
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  • Carlos Augusto Monteiro, São Paulo State University, São Paulo, Brazil
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  • Marc J Gunter, Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Univ Lyon 1, Universite de Lyon (ComUE), Universite Claude Bernard Lyon 1, CHU Lyon, Ctr Hosp Lyon Sud, Hosp Civils Lyon, Dept Chirurg Gen
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  • Christopher Millett, Imperial Coll London, Imperial College London, UKDRI
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  • Heinz Freisling, Nutrition and Metabolism Branch

BACKGROUND: There is a worldwide shift towards increased consumption of ultra-processed foods (UPF) with concurrent rising prevalence of obesity. We examined the relationship between the consumption of UPF and weight gain and risk of obesity.

METHODS: This prospective cohort included 348 748 men and women aged 25-70 years. Participants were recruited between 1992 and 2000 from 9 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Two body weight measures were available, at baseline and after a median follow-up time of 5 years. Foods and drinks were assessed at baseline by dietary questionnaires and classified according to their degree of processing using NOVA classification. Multilevel mixed linear regression was used to estimate the association between UPF consumption and body weight change (kg/5 years). To estimate the relative risk of becoming overweight or obese after 5 years we used Poisson regression stratified according to baseline body mass index (BMI).

RESULTS: After multivariable adjustment, higher UPF consumption (per 1 SD increment) was positively associated with weight gain (0·12 kg/5 years, 95% CI 0·09 to 0·15). Comparing highest vs. lowest quintile of UPF consumption was associated with a 15% greater risk (95% CI 1·11, 1·19) of becoming overweight or obese in normal weight participants, and with a 16% greater risk (95% CI 1·09, 1·23) of becoming obese in participants who were overweight at baseline.

CONCLUSIONS: These results are supportive of public health campaigns to substitute UPF for less processed alternatives for obesity prevention and weight management.

OriginalsprogEngelsk
TidsskriftClinical Nutrition
Vol/bind40
Nummer9
Sider (fra-til)5079-5088
Antal sider10
ISSN0261-5614
DOI
StatusE-pub ahead of print - 21 aug. 2021

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Copyright © 2021. Published by Elsevier Ltd.

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