Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

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  • Mireia Obón-Santacana, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), L'Hospitalet de Llobregat
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  • Leila Luján-Barroso, L'Hospitalet de Llobregat, Universitat de Barcelona
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  • Heinz Freisling, International Agency for Research on Cancer
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  • Sabine Naudin, International Agency for Research on Cancer
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  • Marie Christine Boutron-Ruault, Gustave Roussy, Université Paris-Saclay
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  • Francesca Romana Mancini, Université Paris-Saclay, Gustave Roussy
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  • Vinciane Rebours, Inserm UMR1149, DHU Unit, Paris-Diderot University, Paris, France.
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  • Tilman Kühn, German Cancer Research Center, Heidelberg
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  • Verena Katzke, German Cancer Research Center, Heidelberg
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  • Heiner Boeing, German Institute of Human Nutrition
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  • Anne Tjønneland, Kræftens Bekæmpelse, Kobenhavns Universitet
  • ,
  • Anja Olsen
  • Kim Overvad
  • Cristina Lasheras, Universidad de Oviedo
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  • Miguel Rodríguez-Barranco, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Universidad de Granada
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  • Pilar Amiano, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), BioDonostia Research Institute
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  • Carmen Santiuste, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Murcia Regional Health Council
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  • Eva Ardanaz, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Navarra Public Health Institute, IdiSNA
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  • Kay Thee Khaw, Cambridge University
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  • Nicholas J. Wareham, University of Cambridge, School of Clinical Medicine
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  • Julie A. Schmidt, Cancer Epidemiology Unit, University of Oxford, Oxford
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  • Dagfinn Aune, Imperial College London, Bjørknes University College, University of Oslo, Oslo University Hospital, Oslo
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  • Antonia Trichopoulou, Hellenic Health Foundation, Athens
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  • Paschalis Thriskos, Hellenic Health Foundation, Athens
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  • Eleni Peppa, Hellenic Health Foundation, Athens
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  • Giovanna Masala, Institute for the Study and Prevention of Cancer
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  • Sara Grioni, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
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  • Rosario Tumino, ASP Ragusa
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  • Salvatore Panico, University of Naples Federico II
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  • Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM), Bilthoven, Imperial College London, University of Malaya, University Medical Centre Utrecht
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  • Veronica Sciannameo, Regional Health Service ASL TO3
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  • Roel Vermeulen, Utrecht University
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  • Emily Sonestedt, Lund University
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  • Malin Sund, Clinical Sciences, Umea universitet, Klinisk vetenskap.
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  • Elisabete Weiderpass, UiT The Arctic University of Norway, International Agency for Research on Cancer
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  • Guri Skeie, UiT The Arctic University of Norway
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  • Carlos A. González, L'Hospitalet de Llobregat
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  • Elio Riboli, Imperial College London
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  • Eric J. Duell, L'Hospitalet de Llobregat

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind146
Nummer1
Sider (fra-til)76-84
Antal sider9
ISSN0020-7136
DOI
StatusUdgivet - jan. 2020

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