Consumption of fruits, vegetables, and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

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  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Virginie Béraud, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Silvia Franceschi, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Valerie Cayssials, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Konstantinos Tsilidis, School of Public Health, Imperial College London, London, UK., Storbritannien
  • Marie-Christine Boutron-Ruault, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805 Villejuif, France; Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France., Frankrig
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland., Finland
  • Kim Overvad
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Anne Kirstine Eriksen, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Fabrice Bonnet, CHU Rennes, Rennes 1 University, Rennes, France., Frankrig
  • Aurélie Affret, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805 Villejuif, France; Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France., Frankrig
  • Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Tyskland
  • Antonia Trichopoulou, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Grækenland
  • Elisavet Valanou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Giovanna Masala, Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy., Italien
  • Sara Grioni, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Maria Santucci de Magistris, Department of Clinical and Experimental Medicine, Federico II University, via Pansini 5, 80131 Naples, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Unit "Civic - M.P. Arezzo "Hospital ASP Ragusa, Italy., Italien
  • Fulvio Ricceri, Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Turin, Italy., Italien
  • Guri Skeie, Department of Community Medicine, Faculty of Health Sciences, UiT The Artic University of Tromsø, Tromsø, Norway., Norge
  • Christine L Parr, Domain of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway., Norge
  • Susana Merino, Public Health Directorate, Asturias, Spain., Spanien
  • Elena Salamanca-Fernandez, CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Spanien
  • Maria-Dolores Chirlaque, Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain., Spanien
  • Eva Ardanaz, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia, Spain., Spanien
  • Martin Almquist, Malmö Diet and Cancer Study, University Hospital Malmö, Malmö, Sweden; Departments of., Sverige
  • Isabel Drake, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sverige
  • Joakim Hennings, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • Maria Sandström, Center for Cancer Prevention (CPO-Piemonte), Turin, Italy, Department of Radiation Sciences, Oncology Umeå University, 901 85 Umeå, Sweden., Sverige
  • H Bas Bueno-de-Mesquita, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Holland
  • Petra H Peeters, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands., Holland
  • Kay-Thee Khaw, Department of Public Health and Primary Care, University of Cambridge., Storbritannien
  • Nicholas J. Wareham, MRC Epidemiology Unit and University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Storbritannien
  • Julie A Schmidt, Cancer Epidemiology Unit, University of Oxford, OX30NR Oxford, UK., Storbritannien
  • Aurora Perez-Cornago, Cancer Epidemiology Unit, University of Oxford, OX30NR Oxford, UK., Storbritannien
  • Dagfinn Aune, Bjørknes University College, Oslo, Norway., Norge
  • Elio Riboli, School of Public Health, Imperial College London, London, UK., Storbritannien
  • Nadia Slimani, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Augustin Scalbert, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Isabelle Romieu, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Antonio Agudo, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Sabina Rinaldi, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig

Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind142
Nummer3
Sider (fra-til)449-459
Antal sider11
ISSN0020-7136
DOI
StatusUdgivet - 1 feb. 2018

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