Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. / Wu, Lisa Maria; Amidi, Ali; Tanenbaum, Molly ; Winkel, Gary; Gordon, Wayne; Hall, Simon ; Bovbjerg, Katrin; Diefenbach, Michael .

I: Supportive Care in Cancer, Bind 26, Nr. 6, 2018, s. 1917-1926.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Wu, LM, Amidi, A, Tanenbaum, M, Winkel, G, Gordon, W, Hall, S, Bovbjerg, K & Diefenbach, M 2018, 'Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study', Supportive Care in Cancer, bind 26, nr. 6, s. 1917-1926. https://doi.org/10.1007/s00520-017-4026-8

APA

Wu, L. M., Amidi, A., Tanenbaum, M., Winkel, G., Gordon, W., Hall, S., Bovbjerg, K., & Diefenbach, M. (2018). Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. Supportive Care in Cancer, 26(6), 1917-1926. https://doi.org/10.1007/s00520-017-4026-8

CBE

Wu LM, Amidi A, Tanenbaum M, Winkel G, Gordon W, Hall S, Bovbjerg K, Diefenbach M. 2018. Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. Supportive Care in Cancer. 26(6):1917-1926. https://doi.org/10.1007/s00520-017-4026-8

MLA

Vancouver

Author

Wu, Lisa Maria ; Amidi, Ali ; Tanenbaum, Molly ; Winkel, Gary ; Gordon, Wayne ; Hall, Simon ; Bovbjerg, Katrin ; Diefenbach, Michael . / Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. I: Supportive Care in Cancer. 2018 ; Bind 26, Nr. 6. s. 1917-1926.

Bibtex

@article{3921044c55a84f7c8953af3091dcb724,
title = "Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study",
abstract = "Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment. Methods: Sixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed. Results: Feasibility:A priori feasibility thresholds were partially met (i.e., randomization rate > 50%, retention rate > 70% excluding CCT drop-outs, but < 70% for intent-to-treat). Acceptability: Participants were mostly satisfied with CCT and found it somewhat enjoyable, though barriers to uptake existed. Preliminary efficacy: Linear mixed models indicated significant time by group effects favorable to CCT in reaction time (p =.01), but unfavorable to CCT in verbal and visual memory (ps < .05). Memory was temporarily suppressed in the CCT group at T2, but normalized by T3. There was no effect of CCT on self-reported cognitive functioning, neurobehavioral functioning, nor quality of life. Conclusions: This study provides tentative support for the feasibility and acceptability of CCT to treat mild cognitive impairment in ADT patients. CCT had a beneficial effect on reaction time, but temporarily suppressed memory. CCT{\textquoteright}s benefits may be limited to a narrow area of functioning. Larger-scale studies are needed.",
keywords = "Antiandrogens, Cancer-related cognitive impairment, Cognition, Computers, Hormone therapy, Oncology",
author = "Wu, {Lisa Maria} and Ali Amidi and Molly Tanenbaum and Gary Winkel and Wayne Gordon and Simon Hall and Katrin Bovbjerg and Michael Diefenbach",
year = "2018",
doi = "10.1007/s00520-017-4026-8",
language = "English",
volume = "26",
pages = "1917--1926",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study

AU - Wu, Lisa Maria

AU - Amidi, Ali

AU - Tanenbaum, Molly

AU - Winkel, Gary

AU - Gordon, Wayne

AU - Hall, Simon

AU - Bovbjerg, Katrin

AU - Diefenbach, Michael

PY - 2018

Y1 - 2018

N2 - Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment. Methods: Sixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed. Results: Feasibility:A priori feasibility thresholds were partially met (i.e., randomization rate > 50%, retention rate > 70% excluding CCT drop-outs, but < 70% for intent-to-treat). Acceptability: Participants were mostly satisfied with CCT and found it somewhat enjoyable, though barriers to uptake existed. Preliminary efficacy: Linear mixed models indicated significant time by group effects favorable to CCT in reaction time (p =.01), but unfavorable to CCT in verbal and visual memory (ps < .05). Memory was temporarily suppressed in the CCT group at T2, but normalized by T3. There was no effect of CCT on self-reported cognitive functioning, neurobehavioral functioning, nor quality of life. Conclusions: This study provides tentative support for the feasibility and acceptability of CCT to treat mild cognitive impairment in ADT patients. CCT had a beneficial effect on reaction time, but temporarily suppressed memory. CCT’s benefits may be limited to a narrow area of functioning. Larger-scale studies are needed.

AB - Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment. Methods: Sixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed. Results: Feasibility:A priori feasibility thresholds were partially met (i.e., randomization rate > 50%, retention rate > 70% excluding CCT drop-outs, but < 70% for intent-to-treat). Acceptability: Participants were mostly satisfied with CCT and found it somewhat enjoyable, though barriers to uptake existed. Preliminary efficacy: Linear mixed models indicated significant time by group effects favorable to CCT in reaction time (p =.01), but unfavorable to CCT in verbal and visual memory (ps < .05). Memory was temporarily suppressed in the CCT group at T2, but normalized by T3. There was no effect of CCT on self-reported cognitive functioning, neurobehavioral functioning, nor quality of life. Conclusions: This study provides tentative support for the feasibility and acceptability of CCT to treat mild cognitive impairment in ADT patients. CCT had a beneficial effect on reaction time, but temporarily suppressed memory. CCT’s benefits may be limited to a narrow area of functioning. Larger-scale studies are needed.

KW - Antiandrogens

KW - Cancer-related cognitive impairment

KW - Cognition

KW - Computers

KW - Hormone therapy

KW - Oncology

UR - http://www.scopus.com/inward/record.url?scp=85039838229&partnerID=8YFLogxK

U2 - 10.1007/s00520-017-4026-8

DO - 10.1007/s00520-017-4026-8

M3 - Journal article

C2 - 29282534

VL - 26

SP - 1917

EP - 1926

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 6

ER -