Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy

Jasmine Melissa Madsen; Charlotte Glinge; Reza Jabbari; Lars Nepper-Christensen; Dan Eik Høfsten; Hans-Henrik Tilsted; Lene Holmvang; Frants Pedersen; Francis Richard Joshi; Rikke Sørensen; Lia Evi Bang; Hans Erik Bøtker; Christian Juhl Terkelsen; Michael Mæng; Lisette Okkels Jensen; Jens Aarøe; Henning Kelbæk; Christian Torp-Pedersen; Lars Køber; Jacob Thomsen Lønborg; Thomas Engstrøm

doi:10.1016/j.amjcard.2021.11.014

Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy

Jasmine Melissa Madsen, Charlotte Glinge, Reza Jabbari, Lars Nepper-Christensen, Dan Eik Høfsten, Hans-Henrik Tilsted, Lene Holmvang, Frants Pedersen, Francis Richard Joshi, Rikke Sørensen, Lia Evi Bang, Hans Erik Bøtker, Christian Juhl Terkelsen, Michael Mæng, Lisette Okkels Jensen, Jens Aarøe, Henning Kelbæk, Christian Torp-Pedersen, Lars Køber, Jacob Thomsen LønborgThomas Engstrøm

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy.

Originalsprog	Engelsk
Tidsskrift	The American Journal of Cardiology
Vol/bind	166
Sider (fra-til)	18-24
Antal sider	7
ISSN	0002-9149
DOI	https://doi.org/10.1016/j.amjcard.2021.11.014
Status	Udgivet - mar. 2022

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10.1016/j.amjcard.2021.11.014Licens: CC BY

Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without ThrombectomyForlagets udgivne version, 366 KBLicens: CC BY

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Citationsformater

Madsen, J. M., Glinge, C., Jabbari, R., Nepper-Christensen, L., Høfsten, D. E., Tilsted, H.-H., Holmvang, L., Pedersen, F., Joshi, F. R., Sørensen, R., Bang, L. E., Bøtker, H. E., Terkelsen, C. J., Mæng, M., Jensen, L. O., Aarøe, J., Kelbæk, H., Torp-Pedersen, C., Køber, L., ... Engstrøm, T. (2022). Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy. The American Journal of Cardiology, 166, 18-24. https://doi.org/10.1016/j.amjcard.2021.11.014

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title = "Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy",

abstract = "In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy.",

author = "Madsen, {Jasmine Melissa} and Charlotte Glinge and Reza Jabbari and Lars Nepper-Christensen and H{\o}fsten, {Dan Eik} and Hans-Henrik Tilsted and Lene Holmvang and Frants Pedersen and Joshi, {Francis Richard} and Rikke S{\o}rensen and Bang, {Lia Evi} and B{\o}tker, {Hans Erik} and Terkelsen, {Christian Juhl} and Michael M{\ae}ng and Jensen, {Lisette Okkels} and Jens Aar{\o}e and Henning Kelb{\ae}k and Christian Torp-Pedersen and Lars K{\o}ber and L{\o}nborg, {Jacob Thomsen} and Thomas Engstr{\o}m",

year = "2022",

month = mar,

doi = "10.1016/j.amjcard.2021.11.014",

language = "English",

volume = "166",

pages = "18--24",

journal = "The American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier Inc.",

}

Madsen, JM, Glinge, C, Jabbari, R, Nepper-Christensen, L, Høfsten, DE, Tilsted, H-H, Holmvang, L, Pedersen, F, Joshi, FR, Sørensen, R, Bang, LE, Bøtker, HE , Terkelsen, CJ , Mæng, M, Jensen, LO, Aarøe, J, Kelbæk, H, Torp-Pedersen, C, Køber, L, Lønborg, JT & Engstrøm, T 2022, 'Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy', The American Journal of Cardiology, bind 166, s. 18-24. https://doi.org/10.1016/j.amjcard.2021.11.014

Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy. / Madsen, Jasmine Melissa; Glinge, Charlotte; Jabbari, Reza et al.
I: The American Journal of Cardiology, Bind 166, 03.2022, s. 18-24.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy

AU - Madsen, Jasmine Melissa

AU - Glinge, Charlotte

AU - Jabbari, Reza

AU - Nepper-Christensen, Lars

AU - Høfsten, Dan Eik

AU - Tilsted, Hans-Henrik

AU - Holmvang, Lene

AU - Pedersen, Frants

AU - Joshi, Francis Richard

AU - Sørensen, Rikke

AU - Bang, Lia Evi

AU - Bøtker, Hans Erik

AU - Terkelsen, Christian Juhl

AU - Mæng, Michael

AU - Jensen, Lisette Okkels

AU - Aarøe, Jens

AU - Kelbæk, Henning

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Lønborg, Jacob Thomsen

AU - Engstrøm, Thomas

PY - 2022/3

Y1 - 2022/3

N2 - In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy.

AB - In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy.

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U2 - 10.1016/j.amjcard.2021.11.014

DO - 10.1016/j.amjcard.2021.11.014

M3 - Journal article

C2 - 34930614

SN - 0002-9149

VL - 166

SP - 18

EP - 24

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

ER -

Madsen JM, Glinge C, Jabbari R, Nepper-Christensen L, Høfsten DE, Tilsted HH et al. Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy. The American Journal of Cardiology. 2022 mar.;166:18-24. doi: 10.1016/j.amjcard.2021.11.014