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Comparative genomics reveals the hybrid origin of a macaque group

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Bao Lin Zhang, CAS - Kunming Institute of Zoology
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  • Wu Chen, Guangzhou Zoo & Guangzhou Wildlife Research Center
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  • Zefu Wang, Sichuan University, Nanjing Forestry University
    • ,
  • Wei Pang, CAS - Kunming Institute of Zoology
    • ,
  • Meng Ting Luo, CAS - Kunming Institute of Zoology
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  • Sheng Wang, CAS - Kunming Institute of Zoology
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  • Yong Shao, CAS - Kunming Institute of Zoology
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  • Wen Qiang He, CAS - Kunming Institute of Zoology
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  • Yuan Deng, BGI-Shenzhen, Københavns Universitet
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  • Long Zhou, Zhejiang University
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  • Jiawei Chen, BGI-Shenzhen
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  • Min Min Yang, CAS - Kunming Institute of Zoology
    • ,
  • Yajiang Wu, Guangzhou Zoo & Guangzhou Wildlife Research Center
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  • Lu Wang, Northwest University China
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  • Hugo Fernández-Bellon, Parc de la Ciutadella
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  • Sandra Molloy, Dublin Zoo
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  • Hélène Meunier, Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives
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  • Fanélie Wanert, Université de Strasbourg
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  • Lukas Kuderna, Illumina
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  • Tomas Marques-Bonet, Universitat Pompeu Fabra, ICREA, Centre for Genomic Regulation, Autonomous University of Barcelona
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  • Christian Roos, German Primate Center – Leibniz Institute for Primate Research
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  • Xiao Guang Qi, Northwest University China
    • ,
  • Ming Li, CAS - Institute of Zoology
    • ,
  • Zhijin Liu, Capital Normal University
    • ,
  • Mikkel Heide Schierup
  • David N. Cooper, Cardiff University
    • ,
  • Jianquan Liu, Sichuan University, Lanzhou University
    • ,
  • Yong Tang Zheng, CAS - Kunming Institute of Zoology
    • ,
  • Guojie Zhang, CAS - Kunming Institute of Zoology, Zhejiang University, Københavns Universitet
    • ,
  • Dong Dong Wu, CAS - Kunming Institute of Zoology, Chinese Academy of Sciences

Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.

OriginalsprogEngelsk
Artikelnummereadd3580
TidsskriftScience Advances
Vol/bind9
Nummer22
ISSN2375-2548
DOI
StatusUdgivet - jun. 2023

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