Comorbidity of migraine with ADHD in adults

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Thomas Folkmann Hansen, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University Hospital of Copenhagen, Copenhagen, Denmark. Thomas.hansen@regionh.dk., Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Thomas.hansen@regionh.dk., Danish Headache Center, Neurological department, Copenhagen University Hospital, Nordre Ringevej 69, DK-2600, Glostrup, Denmark. Thomas.hansen@regionh.dk.
  • ,
  • Louise K Hoeffding, Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Denmark
  • ,
  • Lisette Kogelman, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University Hospital of Copenhagen, Copenhagen, Denmark.
  • ,
  • Thilde Marie Haspang, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University Hospital of Copenhagen, Copenhagen, Denmark.
  • ,
  • Henrik Ullum, Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Denmark
  • ,
  • Erik Sørensen, Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Denmark
  • ,
  • Christian Erikstrup
  • Ole Birger Pedersen, Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
  • ,
  • Kaspar René Nielsen
  • Henrik Hjalgrim, Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • ,
  • Helene M Paarup, o Department of Clinical Immunology , Odense University Hospital , Odense , Denmark.
  • ,
  • Thomas Werge, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • ,
  • Kristoffer Burgdorf, Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Denmark

BACKGROUND: Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders.

METHODS: Participants from the Danish Blood Donor Study (N = 26,456, age 18-65, 46% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes.

RESULTS: Migraine was strongly associated with ADHD (OR = 1.8, 95% CI = 1.5-2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes.

CONCLUSION: Migraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.

OriginalsprogEngelsk
TidsskriftBMC Neurology
Vol/bind18
Nummer1
Sider (fra-til)147
ISSN1471-2377
DOI
StatusUdgivet - 16 okt. 2018

Se relationer på Aarhus Universitet Citationsformater

ID: 136784190