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Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke

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Standard

Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. / Østergaard, Leif; Sorensen, A G; Chesler, D A; Weisskoff, R M; Koroshetz, W J; Wu, O; Gyldensted, C; Rosen, B R.

I: Stroke, Bind 31, Nr. 5, 2000, s. 1097-103.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Østergaard, L, Sorensen, AG, Chesler, DA, Weisskoff, RM, Koroshetz, WJ, Wu, O, Gyldensted, C & Rosen, BR 2000, 'Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke', Stroke, bind 31, nr. 5, s. 1097-103. https://doi.org/10.1161/01.STR.31.5.1097

APA

Østergaard, L., Sorensen, A. G., Chesler, D. A., Weisskoff, R. M., Koroshetz, W. J., Wu, O., Gyldensted, C., & Rosen, B. R. (2000). Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke, 31(5), 1097-103. https://doi.org/10.1161/01.STR.31.5.1097

CBE

Østergaard L, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. 2000. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 31(5):1097-103. https://doi.org/10.1161/01.STR.31.5.1097

MLA

Vancouver

Author

Østergaard, Leif ; Sorensen, A G ; Chesler, D A ; Weisskoff, R M ; Koroshetz, W J ; Wu, O ; Gyldensted, C ; Rosen, B R. / Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. I: Stroke. 2000 ; Bind 31, Nr. 5. s. 1097-103.

Bibtex

@article{c61c4160fb3211dd8f9a000ea68e967b,
title = "Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke",
abstract = "BACKGROUND AND PURPOSE: The heterogeneity of microvascular flows is known to be an important determinant of the efficacy of oxygen delivery to tissue. Studies in animals have demonstrated decreased flow heterogeneity (FH) in states of decreased perfusion pressure. The purpose of the present study was to assess microvascular FH changes in acute stroke with use of a novel perfusion-weighted MRI technique and to evaluate the ability of combined diffusion-weighted MRI and FH measurements to predict final infarct size. METHODS: Cerebral blood flow, FH, and plasma mean transit time (MTT) were measured in 11 patients who presented with acute (<12 hours after symptom onset) stroke. Final infarct size was determined with follow-up MRI or CT scanning. RESULTS: In normal brain tissue, the distribution of relative flows was markedly skewed toward high capillary flow velocities. Within regions of decreased cerebral blood flow, plasma MTT was prolonged. Furthermore, subregions were identified with significant loss of the high-flow component of the flow distribution, thereby causing increased homogeneity of flow velocities. In parametric maps that quantify the acute deviation of FH from that of normal tissue, areas of extreme homogenization of capillary flows predicted final infarct size on follow-up scans of 10 of 11 patients. CONCLUSIONS: Flow heterogeneity and MTT can be rapidly assessed as part of a routine clinical MR examination and may provide a tool for planning of individual stroke treatment, as well as in targeting and evaluation of emerging therapeutic strategies.",
keywords = "Acute Disease, Adult, Aged, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Stroke",
author = "Leif {\O}stergaard and Sorensen, {A G} and Chesler, {D A} and Weisskoff, {R M} and Koroshetz, {W J} and O Wu and C Gyldensted and Rosen, {B R}",
year = "2000",
doi = "10.1161/01.STR.31.5.1097",
language = "English",
volume = "31",
pages = "1097--103",
journal = "Stroke",
issn = "0039-2499",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "5",

}

RIS

TY - JOUR

T1 - Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke

AU - Østergaard, Leif

AU - Sorensen, A G

AU - Chesler, D A

AU - Weisskoff, R M

AU - Koroshetz, W J

AU - Wu, O

AU - Gyldensted, C

AU - Rosen, B R

PY - 2000

Y1 - 2000

N2 - BACKGROUND AND PURPOSE: The heterogeneity of microvascular flows is known to be an important determinant of the efficacy of oxygen delivery to tissue. Studies in animals have demonstrated decreased flow heterogeneity (FH) in states of decreased perfusion pressure. The purpose of the present study was to assess microvascular FH changes in acute stroke with use of a novel perfusion-weighted MRI technique and to evaluate the ability of combined diffusion-weighted MRI and FH measurements to predict final infarct size. METHODS: Cerebral blood flow, FH, and plasma mean transit time (MTT) were measured in 11 patients who presented with acute (<12 hours after symptom onset) stroke. Final infarct size was determined with follow-up MRI or CT scanning. RESULTS: In normal brain tissue, the distribution of relative flows was markedly skewed toward high capillary flow velocities. Within regions of decreased cerebral blood flow, plasma MTT was prolonged. Furthermore, subregions were identified with significant loss of the high-flow component of the flow distribution, thereby causing increased homogeneity of flow velocities. In parametric maps that quantify the acute deviation of FH from that of normal tissue, areas of extreme homogenization of capillary flows predicted final infarct size on follow-up scans of 10 of 11 patients. CONCLUSIONS: Flow heterogeneity and MTT can be rapidly assessed as part of a routine clinical MR examination and may provide a tool for planning of individual stroke treatment, as well as in targeting and evaluation of emerging therapeutic strategies.

AB - BACKGROUND AND PURPOSE: The heterogeneity of microvascular flows is known to be an important determinant of the efficacy of oxygen delivery to tissue. Studies in animals have demonstrated decreased flow heterogeneity (FH) in states of decreased perfusion pressure. The purpose of the present study was to assess microvascular FH changes in acute stroke with use of a novel perfusion-weighted MRI technique and to evaluate the ability of combined diffusion-weighted MRI and FH measurements to predict final infarct size. METHODS: Cerebral blood flow, FH, and plasma mean transit time (MTT) were measured in 11 patients who presented with acute (<12 hours after symptom onset) stroke. Final infarct size was determined with follow-up MRI or CT scanning. RESULTS: In normal brain tissue, the distribution of relative flows was markedly skewed toward high capillary flow velocities. Within regions of decreased cerebral blood flow, plasma MTT was prolonged. Furthermore, subregions were identified with significant loss of the high-flow component of the flow distribution, thereby causing increased homogeneity of flow velocities. In parametric maps that quantify the acute deviation of FH from that of normal tissue, areas of extreme homogenization of capillary flows predicted final infarct size on follow-up scans of 10 of 11 patients. CONCLUSIONS: Flow heterogeneity and MTT can be rapidly assessed as part of a routine clinical MR examination and may provide a tool for planning of individual stroke treatment, as well as in targeting and evaluation of emerging therapeutic strategies.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Cerebrovascular Circulation

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Stroke

U2 - 10.1161/01.STR.31.5.1097

DO - 10.1161/01.STR.31.5.1097

M3 - Journal article

C2 - 10797171

VL - 31

SP - 1097

EP - 1103

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 5

ER -