Department of Clinical Medicine

TY - JOUR

T1 - Combinations of self-reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

AU - Mikkelsen, Susan

AU - Dinh, Khoa Manh

AU - Boldsen, Jens Kjærgaard

AU - Pedersen, Ole Birger

AU - Holst, Gitte Juel

AU - Petersen, Mikkel Steen

AU - Kaspersen, Kathrine Agergård

AU - Møller, Bjarne Kuno

AU - Nielsen, Kaspar Rene

AU - Paarup, Helene Martina

AU - Rostgaard, Klaus

AU - Hjalgrim, Henrik

AU - Sørensen, Erik

AU - Handgaard, Linda Jenny

AU - Hansen, Thomas Folkmann

AU - Banasik, Karina

AU - Burgdorf, Kristoffer Sølvsten

AU - Ullum, Henrik

AU - Sigsgaard, Torben

AU - Erikstrup, Christian

N1 - Publisher Copyright: © 2021 The Authors. Clinical and Translational Allergy published by John Wiley and Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.

PY - 2021/3

Y1 - 2021/3

N2 - Background: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives: The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods: From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results: The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion: Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self-reported ARC represent a primarily sIgE-positive phenotype, while those with either AR or AC represent more diverse phenotypes.

AB - Background: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives: The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods: From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results: The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion: Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self-reported ARC represent a primarily sIgE-positive phenotype, while those with either AR or AC represent more diverse phenotypes.

KW - allergic IgE sensitization

KW - asthma

KW - conjunctivitis

KW - environment

KW - rhinitis

KW - allergic IgE sensitization

KW - asthma

KW - conjunctivitis

KW - environment

KW - rhinitis

KW - BLOOD-DONOR

KW - DONATION

KW - ADULTS

KW - ALLERGIC RHINITIS

KW - SYMPTOMS

KW - PREVALENCE

KW - URBAN-RURAL GRADIENT

KW - ASSOCIATION

KW - EXPOSURE

KW - LIFE

U2 - 10.1002/clt2.12013

DO - 10.1002/clt2.12013

M3 - Journal article

C2 - 33900050

VL - 11

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

IS - 1

M1 - e12013

ER -