Combinations of self-reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Susan Mikkelsen
  • Khoa Manh Dinh
  • Jens Kjærgaard Boldsen
  • Ole Birger Pedersen, Sjælland University Hospital
  • ,
  • Gitte Juel Holst, The Danish Clinical Quality Program (RKKP), National Clinical Registries, Aarhus, Denmark.
  • ,
  • Mikkel Steen Petersen
  • Kathrine Agergård Kaspersen
  • Bjarne Kuno Møller
  • Kaspar Rene Nielsen, Aalborg Universitetshospital
  • ,
  • Helene Martina Paarup, Odense Universitetshospital
  • ,
  • Klaus Rostgaard, Statens Serum Institut
  • ,
  • Henrik Hjalgrim, Statens Serum Institut
  • ,
  • Erik Sørensen, Københavns Universitet
  • ,
  • Linda Jenny Handgaard, Københavns Universitet
  • ,
  • Thomas Folkmann Hansen, Københavns Universitet
  • ,
  • Karina Banasik, Københavns Universitet
  • ,
  • Kristoffer Sølvsten Burgdorf, Københavns Universitet
  • ,
  • Henrik Ullum, Københavns Universitet, Statens Serum Institut
  • ,
  • Torben Sigsgaard
  • Christian Erikstrup
Abstract Background Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self-reported ARC represent a primarily sIgE-positive phenotype, while those with either AR or AC represent more diverse phenotypes.
Artikelnummer e12013
TidsskriftClinical and Translational Allergy
Antal sider23
StatusUdgivet - mar. 2021

Bibliografisk note


  • allergic IgE sensitization, asthma, conjunctivitis, environment, rhinitis

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