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Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging. / Klinge, Mette Winther; Krogh, Klaus; Mark, Esben Bolvig et al.
I: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Bind 34, Nr. 9, 14374, 09.2022, s. e14374.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging
AU - Klinge, Mette Winther
AU - Krogh, Klaus
AU - Mark, Esben Bolvig
AU - Drewes, Asbjørn Mohr
AU - Brix, Lau
AU - Isaksen, Christin
AU - Dedelaite, Milda
AU - Frøkjaer, Jens Brøndum
AU - Fynne, Lotte Vinskov
N1 - © 2022 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
PY - 2022/9
Y1 - 2022/9
N2 - BACKGROUND: Functional constipation (FC) and irritable bowel syndrome constipation type (IBS-C) share many similarities, and it remains unknown whether they are distinct entities or part of the same spectrum of disease. Magnetic resonance imaging (MRI) allows quantification of intraluminal fecal volume. We hypothesized that colonic volumes of patients with FC would be larger than those of patients with IBS-C, and that both patient groups would have larger colonic volumes than healthy controls (HC).METHODS: Based on validated questionnaires, three groups of participants were classified into FC (n = 13), IBS-C (n = 10), and HC (n = 19). The colonic volume of each subject was determined by MRI. Stool consistency was described by the Bristol stool scale and colonic transit times were assessed with radiopaque makers.KEY RESULTS: Overall, total colonic volumes were different in the three groups, HC (median 629 ml, interquartile range (IQR)(562-868)), FC (864 ml, IQR(742-940)), and IBS-C (520 ml IQR(489-593)) (p = 0.001). Patients with IBS-C had lower colonic volumes than patients with FC (p = 0.001) and HC (p = 0.019), but there was no difference between FC and HC (p = 0.10). Stool consistency was similar in the two patient groups, but patients with FC had longer colonic transit time than those with IBS-C (117.6 h versus 43.2 h, p = 0.019).CONCLUSION: Patients with IBS-C have lower total colonic volumes and shorter colonic transit times than patients with FC. Future studies are needed to confirm that colonic volume allows objective distinction between the two conditions.
AB - BACKGROUND: Functional constipation (FC) and irritable bowel syndrome constipation type (IBS-C) share many similarities, and it remains unknown whether they are distinct entities or part of the same spectrum of disease. Magnetic resonance imaging (MRI) allows quantification of intraluminal fecal volume. We hypothesized that colonic volumes of patients with FC would be larger than those of patients with IBS-C, and that both patient groups would have larger colonic volumes than healthy controls (HC).METHODS: Based on validated questionnaires, three groups of participants were classified into FC (n = 13), IBS-C (n = 10), and HC (n = 19). The colonic volume of each subject was determined by MRI. Stool consistency was described by the Bristol stool scale and colonic transit times were assessed with radiopaque makers.KEY RESULTS: Overall, total colonic volumes were different in the three groups, HC (median 629 ml, interquartile range (IQR)(562-868)), FC (864 ml, IQR(742-940)), and IBS-C (520 ml IQR(489-593)) (p = 0.001). Patients with IBS-C had lower colonic volumes than patients with FC (p = 0.001) and HC (p = 0.019), but there was no difference between FC and HC (p = 0.10). Stool consistency was similar in the two patient groups, but patients with FC had longer colonic transit time than those with IBS-C (117.6 h versus 43.2 h, p = 0.019).CONCLUSION: Patients with IBS-C have lower total colonic volumes and shorter colonic transit times than patients with FC. Future studies are needed to confirm that colonic volume allows objective distinction between the two conditions.
KW - irritable bowel syndrome
KW - magnet resonance imaging
KW - colonic volume
KW - functional constipation
KW - colonic transit time
KW - DEMOGRAPHICS
KW - SUBTYPES
KW - SYMPTOMS
KW - TIME
KW - VARIABILITY
KW - GASTROINTESTINAL TRANSIT
KW - DEFECATION
KW - STOOL FORM
KW - SCALE
KW - EPIDEMIOLOGY
KW - Humans
KW - Gastrointestinal Transit
KW - Magnetic Resonance Imaging
KW - Irritable Bowel Syndrome
KW - Constipation
U2 - 10.1111/nmo.14374
DO - 10.1111/nmo.14374
M3 - Journal article
C2 - 35383405
VL - 34
SP - e14374
JO - Neurogastroenterology and Motility Online
JF - Neurogastroenterology and Motility Online
SN - 1365-2982
IS - 9
M1 - 14374
ER -