Collagenase Motors in Gelatine-Based Hydrogels

Nanying Wang; Thaís Floriano Marcelino; Carina Aileen Ade; Stefan Pendlmayr; Miguel Alexandre Ramos Docampo; Brigitte Maria Stadler

doi:10.1039/d3nr05712g

Collagenase Motors in Gelatine-Based Hydrogels

Nanying Wang, Thaís Floriano Marcelino, Carina Aileen Ade, Stefan Pendlmayr, Miguel Alexandre Ramos Docampo, Brigitte Maria Stadler^*

^*Corresponding author af dette arbejde

Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors’ size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s⁻¹ in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.

Originalsprog	Engelsk
Tidsskrift	Nanoscale
Vol/bind	16
Nummer	20
Sider (fra-til)	9935-9943
Antal sider	9
ISSN	2040-3364
DOI	https://doi.org/10.1039/d3nr05712g
Status	Udgivet - maj 2024

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10.1039/d3nr05712g

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title = "Collagenase Motors in Gelatine-Based Hydrogels",

abstract = "Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors{\textquoteright} size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s−1 in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.",

author = "Nanying Wang and Marcelino, {Tha{\'i}s Floriano} and Ade, {Carina Aileen} and Stefan Pendlmayr and {Ramos Docampo}, {Miguel Alexandre} and Stadler, {Brigitte Maria}",

year = "2024",

month = may,

doi = "10.1039/d3nr05712g",

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AU - Wang, Nanying

AU - Marcelino, Thaís Floriano

AU - Ade, Carina Aileen

AU - Pendlmayr, Stefan

AU - Ramos Docampo, Miguel Alexandre

AU - Stadler, Brigitte Maria

PY - 2024/5

Y1 - 2024/5

N2 - Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors’ size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s−1 in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.

AB - Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors’ size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s−1 in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.

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U2 - 10.1039/d3nr05712g

DO - 10.1039/d3nr05712g

M3 - Journal article

C2 - 38690802

SN - 2040-3364

VL - 16

SP - 9935

EP - 9943

JO - Nanoscale

JF - Nanoscale

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ER -

Collagenase Motors in Gelatine-Based Hydrogels

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