Co-immobilization of Ce6 Sono/photosensitizer and Protonated Graphitic-Carbon Nitride on PCL/gelation Fibrous Scaffolds For Combined Sono-photodynamic Cancer Therapy

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Co-immobilization of Ce6 Sono/photosensitizer and Protonated Graphitic-Carbon Nitride on PCL/gelation Fibrous Scaffolds For Combined Sono-photodynamic Cancer Therapy. / Sun, Di; Zhang, Zhongyang; Chen, Mengya; Zhang, Yanping; Amagat, Jordi; Kang, Shifei; Zheng, Yuanyi; Hu, Bing; Chen, Menglin.

I: ACS applied materials & interfaces, Bind 12, Nr. 36, 2020, s. 40728-40739.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{21307ee87ae849a4a02f4a5843db9dcf,
title = "Co-immobilization of Ce6 Sono/photosensitizer and Protonated Graphitic-Carbon Nitride on PCL/gelation Fibrous Scaffolds For Combined Sono-photodynamic Cancer Therapy",
abstract = "Aiming at developing moderate and efficient sono-photodynamic therapy of breast cancer, tissue engineering scaffolds may provide an easy and efficient strategy to eliminate serious side effects in conventional surgery or chemotherapy, and thus, they are highly desired. However, the development of ideal sono-photodynamic therapeutic scaffolds is always hindered by the poor stability and incompatibility between the different biomaterial components. Herein, the FDA-approved sono/photosensitizer Ce6 was successfully and tightly incorporated into electrospun polycaprolactone/gelatin (PG) scaffolds via positively charged protonated g-C3N4 nanosheets (pCN). The PG fibers were precoated with graphene oxide (GO) to enable the assembly of pCN on the surface through electrostatic interactions. The Ce6@pCN-GO-PG composite scaffolds exhibited good cytocompatibility and excellent sono-photodynamic activity, leading to distinctly boosted reactive oxygen species (ROS) generation and a 95.8% inactivation rate of breast cancer cells through a synergistic sono-photodynamic process triggered by an 808 nm laser and 1 M Hz ultrasound excitation, within the clinical therapeutic dose. The as-developed scaffolds with unique ultrasound cavitation therapeutic effects can be used not only for complete eradication of tumor cells after surgery, but also as a cell behavior observation platform of sono-photodynamic cancer therapy.",
author = "Di Sun and Zhongyang Zhang and Mengya Chen and Yanping Zhang and Jordi Amagat and Shifei Kang and Yuanyi Zheng and Bing Hu and Menglin Chen",
year = "2020",
doi = "10.1021/acsami.0c08446",
language = "English",
volume = "12",
pages = "40728--40739",
journal = "A C S Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "36",

}

RIS

TY - JOUR

T1 - Co-immobilization of Ce6 Sono/photosensitizer and Protonated Graphitic-Carbon Nitride on PCL/gelation Fibrous Scaffolds For Combined Sono-photodynamic Cancer Therapy

AU - Sun, Di

AU - Zhang, Zhongyang

AU - Chen, Mengya

AU - Zhang, Yanping

AU - Amagat, Jordi

AU - Kang, Shifei

AU - Zheng, Yuanyi

AU - Hu, Bing

AU - Chen, Menglin

PY - 2020

Y1 - 2020

N2 - Aiming at developing moderate and efficient sono-photodynamic therapy of breast cancer, tissue engineering scaffolds may provide an easy and efficient strategy to eliminate serious side effects in conventional surgery or chemotherapy, and thus, they are highly desired. However, the development of ideal sono-photodynamic therapeutic scaffolds is always hindered by the poor stability and incompatibility between the different biomaterial components. Herein, the FDA-approved sono/photosensitizer Ce6 was successfully and tightly incorporated into electrospun polycaprolactone/gelatin (PG) scaffolds via positively charged protonated g-C3N4 nanosheets (pCN). The PG fibers were precoated with graphene oxide (GO) to enable the assembly of pCN on the surface through electrostatic interactions. The Ce6@pCN-GO-PG composite scaffolds exhibited good cytocompatibility and excellent sono-photodynamic activity, leading to distinctly boosted reactive oxygen species (ROS) generation and a 95.8% inactivation rate of breast cancer cells through a synergistic sono-photodynamic process triggered by an 808 nm laser and 1 M Hz ultrasound excitation, within the clinical therapeutic dose. The as-developed scaffolds with unique ultrasound cavitation therapeutic effects can be used not only for complete eradication of tumor cells after surgery, but also as a cell behavior observation platform of sono-photodynamic cancer therapy.

AB - Aiming at developing moderate and efficient sono-photodynamic therapy of breast cancer, tissue engineering scaffolds may provide an easy and efficient strategy to eliminate serious side effects in conventional surgery or chemotherapy, and thus, they are highly desired. However, the development of ideal sono-photodynamic therapeutic scaffolds is always hindered by the poor stability and incompatibility between the different biomaterial components. Herein, the FDA-approved sono/photosensitizer Ce6 was successfully and tightly incorporated into electrospun polycaprolactone/gelatin (PG) scaffolds via positively charged protonated g-C3N4 nanosheets (pCN). The PG fibers were precoated with graphene oxide (GO) to enable the assembly of pCN on the surface through electrostatic interactions. The Ce6@pCN-GO-PG composite scaffolds exhibited good cytocompatibility and excellent sono-photodynamic activity, leading to distinctly boosted reactive oxygen species (ROS) generation and a 95.8% inactivation rate of breast cancer cells through a synergistic sono-photodynamic process triggered by an 808 nm laser and 1 M Hz ultrasound excitation, within the clinical therapeutic dose. The as-developed scaffolds with unique ultrasound cavitation therapeutic effects can be used not only for complete eradication of tumor cells after surgery, but also as a cell behavior observation platform of sono-photodynamic cancer therapy.

U2 - 10.1021/acsami.0c08446

DO - 10.1021/acsami.0c08446

M3 - Journal article

C2 - 32794726

VL - 12

SP - 40728

EP - 40739

JO - A C S Applied Materials and Interfaces

JF - A C S Applied Materials and Interfaces

SN - 1944-8244

IS - 36

ER -