Co-delivery of siRNA and doxorubicin to cancer cells from additively manufactured implants

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DOI

  • Muwan Chen
  • Morten Østergaard Andersen, Syddansk Universitet, Interdisciplinary Nanoscience Center, Aarhus University, Orthopaedic Research Laboratory, Aarhus University Hospital, Department of Molecular Biology and Genetics - Aarhus University, Danmark
  • Philipp Dillschneider, Danmark
  • Chi-Chih (Clare) Chang, Danmark
  • Shan Gao, Danmark
  • Dang Quang Svend Le
  • Chuanxu Yang, Danmark
  • San Hein, Danmark
  • Cody Bünger
  • Jørgen Kjems
Tumors in load bearing bone tissue are a major clinical problem, in part because surgical resection invokes a dilemma whether to resect aggressively, risking mechanical failure, or to resect conservatively, risking cancer recurrence due to residual malignant cells. A chemo-functionalized implant, capable of physically supporting the void while killing residual cancer cells, would be an attractive solution. Here we describe a novel additively manufactured implant that can be functionalized with chitosan/siRNA nanoparticles. These induce long term gene silencing in adjacent cancer cells without showing toxicity to normal cells. When scaffolds are functionalized with siRNA/chitosan nanoparticles and doxorubicin in combination, their effects synergized leading to cancer cell death. This technology may be used to target resistance genes by RNA interference and thereby re-sensitizing the cancer cells to co-delivered chemotherapy.
OriginalsprogEngelsk
TidsskriftRSC Advances
Vol/bind5
Sider (fra-til)101718-101725
Antal sider8
ISSN2046-2069
DOI
StatusUdgivet - 16 nov. 2015

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