Close linkage between X-linked ectodermal dysplasia and a cloned DNA sequence detecting a two allele restriction fragment length polymorphism in the region Xp11-q12

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  • Steen Kølvraa
  • ,
  • Torben A. Kruse, Aarhus Universitet
  • ,
  • P. K.A. Jensen
  • ,
  • Kirsten H. Linde, Aarhus Universitet
  • ,
  • Søren R. Vestergaard, Aarhus Universitet
  • ,
  • Lars Bolund

EDA (ectodermal dysplasia, anhidrotic) is an X-linked recessive disorder characterized by hypohidrosis, hypoor anodontia, and hypotrichosis. A possible linkage between the gene for EDA and a number of restriction fragment length polymorphisms (RFLPs) spread over the X chromosome was investigated in two Danish families segregating EDA. No recombination between the gene for EDA and our probe pTAK8, which detects a two allele polymorphism in the region Xp11-q12, was found in nine informative meiotic events (seven of which are phase known), giving a maximal lod score of 2.41 at a recombination fraction of 0.00. This juxtacentromeric location of the gene for EDA agrees well with the linkage data obtained with the other markers used in this study.

TidsskriftHuman Genetics
Sider (fra-til)284-287
Antal sider4
StatusUdgivet - 1 nov. 1986

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