Clinical validation of ratings on the six-item Positive and Negative Syndrome Scale obtained via the Simplified Negative and Positive Symptoms Interview

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Pernille Kølbæk
  • David Dines, Aarhus Universitet
  • ,
  • Tine Holm
  • Anne B. Blicher, Aarhus Universitet
  • ,
  • Rune D. Sørensen, Aarhus Universitet
  • ,
  • Kathrine M. O’Leary, Aarhus Universitet
  • ,
  • Sandra G. Feller, Aarhus Universitet
  • ,
  • Chanette W. Buus, Aarhus Universitet
  • ,
  • Cecilie M. Nielsen
  • Mark Opler, MedAvante-ProPhase Inc, New York University
  • ,
  • Ole Mors
  • Christoph U. Correll, Zucker Hillside Hospital, Hofstra University, Charité-Universitätsmedizin Berlin
  • ,
  • Søren D. Østergaard

Background: The six-item version of the Positive and Negative Syndrome Scale (PANSS-6) has shown promise as a brief measure of the severity of core symptoms of schizophrenia. However, since all prior analyses of the PANSS-6 were based on data extracted from studies using the full 30-item PANSS (PANSS-30), it remains unknown whether it is possible to obtain valid information for the PANSS-6 ratings via a brief interview, such as the Simplified Negative and Positive Symptoms Interview (SNAPSI). Aims: We aimed to validate the PANSS-6 ratings obtained via the SNAPSI using the PANSS-6 scores extracted from the PANSS-30 ratings obtained via the comprehensive Structured Clinical Interview for PANSS (SCI-PANSS) as the gold-standard reference. Methods: The PANSS-6 ratings based on the SNAPSI and the PANSS-30 ratings based on the SCI-PANSS were conducted by independent raters with established inter-rater reliability. Results: Seventy-seven inpatients with schizophrenia (Mage = 35.1 ± 11.7 years; males = 57%; paranoid schizophrenia = 75%) participated in the study. The intraclass correlation coefficient (ICC) of the PANSS-6 total scores obtained using the SNAPSI and the PANSS-30-derived PANSS-6 total scores via the SCI-PANSS was 0.77 (p < 0.001). The ICC for the PANSS-6 total score and the PANSS-30-derived PANSS-8 (Andreasen’s remission criteria) was 0.75 (p < 0.001). Spearman’s rank correlation coefficient for changes in PANSS-6 total scores via the SNAPSI and changes in PANSS-30-derived PANSS-6 total scores was 0.70 (p < 0.001). Conclusions: Using the SNAPSI to rate the PANSS-6 enables a focused and brief assessment of the severity of core symptoms of schizophrenia, which facilitates measurement-based care and clinical decision making in the treatment of schizophrenia.

OriginalsprogEngelsk
TidsskriftJournal of Psychopharmacology
ISSN0269-8811
DOI
StatusAccepteret/In press - 2021

Bibliografisk note

Funding Information:
The authors declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: Dr Opler is a full-time employee of MedAvante-ProPhase Inc. Dr Correll has been a consultant and/or adviser to or has received honoraria from: Acadia, Alkermes, Allergan, Angelini, Axsome, Gedeon Richter, Gerson Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Sumitomo Dainippon, Sunovion, Supernus, Takeda and Teva. He has provided expert testimony for Janssen and Otsuka. He served on a Data Safety Monitoring Board for Lundbeck, Rovi, Supernus and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma. Dr Dines has received financial support from Lundbeck to cover expenses for travel/accommodation in relation to conference participation. The remaining authors declare no conflicts of interest. Aarhus University, The Feinstein Institute for Medical Research and MedAvante-ProPhase Inc. each hold one-third of the copyright for the Simplified Negative and Positive Symptoms Interview (SNAPSI).

Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from The Independent Research Fund Denmark, Aarhus University Research Foundation, The Riisfort Foundation and The Faculty of Health — Aarhus University.

Publisher Copyright:
© The Author(s) 2021.

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