Clinical implications of early caudate dysfunction in Parkinson's disease

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  • Jacopo Pasquini, IRCCS Ist Auxol Italiano, IRCCS Istituto Auxologico Italiano, Lab Neurosci
  • ,
  • Rory Durcan, Newcastle Univ, Newcastle University - UK, Inst Neurosci
  • ,
  • Louise Wiblin, Newcastle Univ, Newcastle University - UK, Inst Neurosci
  • ,
  • Morten Gersel Stokholm
  • Lynn Rochester, Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne Hospitals NHS Foundation Trust
  • ,
  • David James Brooks
  • David Burn, Newcastle Univ, Newcastle University - UK, Fac Med Sci
  • ,
  • Nicola Pavese

Objective Although not typical of Parkinson's disease (PD), caudate dopaminergic dysfunction can occur in early stages of the disease. However, its frequency and longitudinal implications in large cohorts of recently diagnosed patients remain to be established. We investigated the occurrence of caudate dopaminergic dysfunction in the very early phases of PD (

Methods Patients with PD and healthy controls were identified from the Parkinson's Progression Markers Initiative (PPMI) database. We defined a clinically significant caudate dysfunction as I-123-FP-CIT binding

Results At baseline, 51.6% of 397 patients had normal caudate dopamine transporter binding, 26.0% had unilateral caudate involvement, 22.4% had bilaterally impaired caudate. Compared with those with a baseline normal caudate function, at the 4-year follow-up patients with a baseline bilateral caudate involvement showed a higher frequency of cognitive impairment (p

Conclusions Early significant caudate dopaminergic denervation was found in half of the cases in the PPMI series. Baseline bilateral caudate involvement was associated with increased risk of developing cognitive impairment, depression and gait problems over the next 4 years.

TidsskriftJournal of Neurology Neurosurgery and Psychiatry
Sider (fra-til)1098-1104
Antal sider7
StatusUdgivet - okt. 2019
Eksternt udgivetJa

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