Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

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Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease. / Bellini, Gabriele; Best, Laura A.; Brechany, Una; Mills, Russell; Pavese, Nicola.

I: Movement Disorders Clinical Practice, Bind 7, Nr. 4, 05.2020, s. 373-382.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Harvard

Bellini, G, Best, LA, Brechany, U, Mills, R & Pavese, N 2020, 'Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease', Movement Disorders Clinical Practice, bind 7, nr. 4, s. 373-382. https://doi.org/10.1002/mdc3.12938

APA

Bellini, G., Best, L. A., Brechany, U., Mills, R., & Pavese, N. (2020). Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease. Movement Disorders Clinical Practice, 7(4), 373-382. https://doi.org/10.1002/mdc3.12938

CBE

Bellini G, Best LA, Brechany U, Mills R, Pavese N. 2020. Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease. Movement Disorders Clinical Practice. 7(4):373-382. https://doi.org/10.1002/mdc3.12938

MLA

Vancouver

Bellini G, Best LA, Brechany U, Mills R, Pavese N. Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease. Movement Disorders Clinical Practice. 2020 maj;7(4):373-382. https://doi.org/10.1002/mdc3.12938

Author

Bellini, Gabriele ; Best, Laura A. ; Brechany, Una ; Mills, Russell ; Pavese, Nicola. / Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease. I: Movement Disorders Clinical Practice. 2020 ; Bind 7, Nr. 4. s. 373-382.

Bibtex

@article{de884fa128d845759f43f62d532689c0,
title = "Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease",
abstract = "Background: The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non-motor phenomena. Objectives: We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods: We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results: Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo-regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions: DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.",
keywords = "autonomic system, deep brain stimulation, globus pallidus interna, Parkinson's disease, subthalamic nucleus",
author = "Gabriele Bellini and Best, {Laura A.} and Una Brechany and Russell Mills and Nicola Pavese",
year = "2020",
month = may,
doi = "10.1002/mdc3.12938",
language = "English",
volume = "7",
pages = "373--382",
journal = "Movement Disorders Clinical Practice",
issn = "2330-1619",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

AU - Bellini, Gabriele

AU - Best, Laura A.

AU - Brechany, Una

AU - Mills, Russell

AU - Pavese, Nicola

PY - 2020/5

Y1 - 2020/5

N2 - Background: The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non-motor phenomena. Objectives: We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods: We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results: Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo-regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions: DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.

AB - Background: The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non-motor phenomena. Objectives: We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods: We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results: Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo-regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions: DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.

KW - autonomic system

KW - deep brain stimulation

KW - globus pallidus interna

KW - Parkinson's disease

KW - subthalamic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85082941299&partnerID=8YFLogxK

U2 - 10.1002/mdc3.12938

DO - 10.1002/mdc3.12938

M3 - Review

C2 - 32373653

AN - SCOPUS:85082941299

VL - 7

SP - 373

EP - 382

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

SN - 2330-1619

IS - 4

ER -