Clinical aspects of altered glycosylation of glycoproteins in cancer

Torben F. Ørntoft; Else Marie Vestergaard

doi:10.1002/(SICI)1522-2683(19990201)20:2<362::AID-ELPS362>3.0.CO;2-V

Clinical aspects of altered glycosylation of glycoproteins in cancer

Torben F. Ørntoft^*, Else Marie Vestergaard

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin - Urinvejskirurgi

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

162 Citationer (Scopus)

Abstract

Alteration of the expression of carbohydrate structures is frequently observed in tumor cells. This review summarizes the different changes of O- and N-linked glycoproteins observed in cancer cells, the impact of the tumor- related carbohydrate phenotypes on the clinical outcome of the cancer disease, and the various ways in which carbohydrate structures can interact with different carbohydrate-detecting adhesion molecules, selectins, and sialoadhesins. Various ways of inhibiting the formation of cell adhesion- engaged carbohydrates on the cell surface, or inhibiting the binding are discussed. Carbohydrate structures which are in clinical use as circulating tumor markers and the effect of genotypes on tumor marker concentrations are reviewed.

Originalsprog	Engelsk
Tidsskrift	Electrophoresis
Vol/bind	20
Nummer	2
Sider (fra-til)	362-371
Antal sider	10
ISSN	0173-0835
DOI	https://doi.org/10.1002/(SICI)1522-2683(19990201)20:2<362::AID-ELPS362>3.0.CO;2-V
Status	Udgivet - 1 jan. 1999

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10.1002/(SICI)1522-2683(19990201)20:2<362::AID-ELPS362>3.0.CO;2-V

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Citationsformater

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title = "Clinical aspects of altered glycosylation of glycoproteins in cancer",

abstract = "Alteration of the expression of carbohydrate structures is frequently observed in tumor cells. This review summarizes the different changes of O- and N-linked glycoproteins observed in cancer cells, the impact of the tumor- related carbohydrate phenotypes on the clinical outcome of the cancer disease, and the various ways in which carbohydrate structures can interact with different carbohydrate-detecting adhesion molecules, selectins, and sialoadhesins. Various ways of inhibiting the formation of cell adhesion- engaged carbohydrates on the cell surface, or inhibiting the binding are discussed. Carbohydrate structures which are in clinical use as circulating tumor markers and the effect of genotypes on tumor marker concentrations are reviewed.",

keywords = "Cancer, Carbohydrate antigens, Cell adhesion, Glycosylation, Review",

author = "{\O}rntoft, {Torben F.} and Vestergaard, {Else Marie}",

year = "1999",

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AU - Ørntoft, Torben F.

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N2 - Alteration of the expression of carbohydrate structures is frequently observed in tumor cells. This review summarizes the different changes of O- and N-linked glycoproteins observed in cancer cells, the impact of the tumor- related carbohydrate phenotypes on the clinical outcome of the cancer disease, and the various ways in which carbohydrate structures can interact with different carbohydrate-detecting adhesion molecules, selectins, and sialoadhesins. Various ways of inhibiting the formation of cell adhesion- engaged carbohydrates on the cell surface, or inhibiting the binding are discussed. Carbohydrate structures which are in clinical use as circulating tumor markers and the effect of genotypes on tumor marker concentrations are reviewed.

AB - Alteration of the expression of carbohydrate structures is frequently observed in tumor cells. This review summarizes the different changes of O- and N-linked glycoproteins observed in cancer cells, the impact of the tumor- related carbohydrate phenotypes on the clinical outcome of the cancer disease, and the various ways in which carbohydrate structures can interact with different carbohydrate-detecting adhesion molecules, selectins, and sialoadhesins. Various ways of inhibiting the formation of cell adhesion- engaged carbohydrates on the cell surface, or inhibiting the binding are discussed. Carbohydrate structures which are in clinical use as circulating tumor markers and the effect of genotypes on tumor marker concentrations are reviewed.

KW - Cancer

KW - Carbohydrate antigens

KW - Cell adhesion

KW - Glycosylation

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=0033048787&partnerID=8YFLogxK

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DO - 10.1002/(SICI)1522-2683(19990201)20:2<362::AID-ELPS362>3.0.CO;2-V

M3 - Review

C2 - 10197444

AN - SCOPUS:0033048787

SN - 0173-0835

VL - 20

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JO - Electrophoresis

JF - Electrophoresis

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ER -

Clinical aspects of altered glycosylation of glycoproteins in cancer

Abstract

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