Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study

Thomas Emmanuel; Annita Petersen; Hannah Inez Houborg; Anders Benjamin Rønsholdt; Dorte Lybæk; Torben Steiniche; Anne Bregnhøj; Lars Iversen; Claus Johansen

doi:10.1111/exd.14549

Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study

Thomas Emmanuel^*, Annita Petersen, Hannah Inez Houborg, Anders Benjamin Rønsholdt, Dorte Lybæk, Torben Steiniche, Anne Bregnhøj, Lars Iversen, Claus Johansen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

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Abstract

Climatotherapy is a well-described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient-reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non-lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c-reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level.

Originalsprog	Engelsk
Tidsskrift	Experimental Dermatology
Vol/bind	31
Nummer	8
Sider (fra-til)	1136-1144
Antal sider	9
ISSN	1600-0625
DOI	https://doi.org/10.1111/exd.14549
Status	Udgivet - aug. 2022

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10.1111/exd.14549Licens: CC BY-NC

Experimental Dermatology - 2022 - Emmanuel - Climatotherapy at the Dead Sea for psoriasis is a highly effectiveForlagets udgivne version, 16,6 MBLicens: CC BY-NC

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title = "Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study",

abstract = "Climatotherapy is a well-described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient-reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non-lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c-reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level.",

keywords = "heliotherapy, immunohistochemistry, inflammation, phototherapy, psoriasis",

author = "Thomas Emmanuel and Annita Petersen and Houborg, {Hannah Inez} and R{\o}nsholdt, {Anders Benjamin} and Dorte Lyb{\ae}k and Torben Steiniche and Anne Bregnh{\o}j and Lars Iversen and Claus Johansen",

year = "2022",

month = aug,

doi = "10.1111/exd.14549",

language = "English",

volume = "31",

pages = "1136--1144",

journal = "Experimental Dermatology",

issn = "1600-0625",

publisher = "Jossey-Bass",

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Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study. / Emmanuel, Thomas; Petersen, Annita; Houborg, Hannah Inez et al.
I: Experimental Dermatology, Bind 31, Nr. 8, 08.2022, s. 1136-1144.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term

T2 - An immunohistochemical study

AU - Emmanuel, Thomas

AU - Petersen, Annita

AU - Houborg, Hannah Inez

AU - Rønsholdt, Anders Benjamin

AU - Lybæk, Dorte

AU - Steiniche, Torben

AU - Bregnhøj, Anne

AU - Iversen, Lars

AU - Johansen, Claus

PY - 2022/8

Y1 - 2022/8

N2 - Climatotherapy is a well-described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient-reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non-lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c-reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level.

AB - Climatotherapy is a well-described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient-reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non-lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c-reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level.

KW - heliotherapy

KW - immunohistochemistry

KW - inflammation

KW - phototherapy

KW - psoriasis

UR - http://www.scopus.com/inward/record.url?scp=85125408934&partnerID=8YFLogxK

U2 - 10.1111/exd.14549

DO - 10.1111/exd.14549

M3 - Journal article

C2 - 35196397

SN - 1600-0625

VL - 31

SP - 1136

EP - 1144

JO - Experimental Dermatology

JF - Experimental Dermatology

IS - 8

ER -