Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition. / Bradbury, Kathryn E; Appleby, Paul N; Tipper, Sarah J; Travis, Ruth C; Allen, Naomi E; Kvaskoff, Marina; Overvad, Kim; Tjønneland, Anne; Halkjaer, Jytte; Cevenka, Iris; Mahamat-Saleh, Yahya; Bonnet, Fabrice; Kaaks, Rudolf; Turzanski Fortner, Renée; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Stratigos, Alexander J; Palli, Domenico; Grioni, Sara; Matullo, Giuseppe; Panico, Salvatore; Tumino, Rosario; Peeters, Petra H; Bueno-de-Mesquita, Bas; Ghiasvand, Reza; Veierød, Marit B; Weiderpass, Elisabete; Bonet, Catalina; Molina, Elena; Huerta, José María; Larrañaga, Nerea; Barricarte, Aurelio; Merino, Susana; Isaksson, Karolin; Stocks, Tanja; Ljuslinder, Ingrid; Hemmingsson, Oskar; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc J; Rinaldi, Sabina; Tsilidis, Konstantinos K; Aune, Dagfinn; Riboli, Elio; Key, Timothy J.

I: International Journal of Cancer, Bind 144, Nr. 5, 01.03.2019, s. 957-966.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bradbury, KE, Appleby, PN, Tipper, SJ, Travis, RC, Allen, NE, Kvaskoff, M, Overvad, K, Tjønneland, A, Halkjaer, J, Cevenka, I, Mahamat-Saleh, Y, Bonnet, F, Kaaks, R, Turzanski Fortner, R, Boeing, H, Trichopoulou, A, La Vecchia, C, Stratigos, AJ, Palli, D, Grioni, S, Matullo, G, Panico, S, Tumino, R, Peeters, PH, Bueno-de-Mesquita, B, Ghiasvand, R, Veierød, MB, Weiderpass, E, Bonet, C, Molina, E, Huerta, JM, Larrañaga, N, Barricarte, A, Merino, S, Isaksson, K, Stocks, T, Ljuslinder, I, Hemmingsson, O, Wareham, N, Khaw, K-T, Gunter, MJ, Rinaldi, S, Tsilidis, KK, Aune, D, Riboli, E & Key, TJ 2019, 'Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, bind 144, nr. 5, s. 957-966. https://doi.org/10.1002/ijc.31854

APA

Bradbury, K. E., Appleby, P. N., Tipper, S. J., Travis, R. C., Allen, N. E., Kvaskoff, M., Overvad, K., Tjønneland, A., Halkjaer, J., Cevenka, I., Mahamat-Saleh, Y., Bonnet, F., Kaaks, R., Turzanski Fortner, R., Boeing, H., Trichopoulou, A., La Vecchia, C., Stratigos, A. J., Palli, D., ... Key, T. J. (2019). Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 144(5), 957-966. https://doi.org/10.1002/ijc.31854

CBE

Bradbury KE, Appleby PN, Tipper SJ, Travis RC, Allen NE, Kvaskoff M, Overvad K, Tjønneland A, Halkjaer J, Cevenka I, Mahamat-Saleh Y, Bonnet F, Kaaks R, Turzanski Fortner R, Boeing H, Trichopoulou A, La Vecchia C, Stratigos AJ, Palli D, Grioni S, Matullo G, Panico S, Tumino R, Peeters PH, Bueno-de-Mesquita B, Ghiasvand R, Veierød MB, Weiderpass E, Bonet C, Molina E, Huerta JM, Larrañaga N, Barricarte A, Merino S, Isaksson K, Stocks T, Ljuslinder I, Hemmingsson O, Wareham N, Khaw K-T, Gunter MJ, Rinaldi S, Tsilidis KK, Aune D, Riboli E, Key TJ. 2019. Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 144(5):957-966. https://doi.org/10.1002/ijc.31854

MLA

Vancouver

Bradbury KE, Appleby PN, Tipper SJ, Travis RC, Allen NE, Kvaskoff M o.a. Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 2019 mar 1;144(5):957-966. https://doi.org/10.1002/ijc.31854

Author

Bradbury, Kathryn E ; Appleby, Paul N ; Tipper, Sarah J ; Travis, Ruth C ; Allen, Naomi E ; Kvaskoff, Marina ; Overvad, Kim ; Tjønneland, Anne ; Halkjaer, Jytte ; Cevenka, Iris ; Mahamat-Saleh, Yahya ; Bonnet, Fabrice ; Kaaks, Rudolf ; Turzanski Fortner, Renée ; Boeing, Heiner ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Stratigos, Alexander J ; Palli, Domenico ; Grioni, Sara ; Matullo, Giuseppe ; Panico, Salvatore ; Tumino, Rosario ; Peeters, Petra H ; Bueno-de-Mesquita, Bas ; Ghiasvand, Reza ; Veierød, Marit B ; Weiderpass, Elisabete ; Bonet, Catalina ; Molina, Elena ; Huerta, José María ; Larrañaga, Nerea ; Barricarte, Aurelio ; Merino, Susana ; Isaksson, Karolin ; Stocks, Tanja ; Ljuslinder, Ingrid ; Hemmingsson, Oskar ; Wareham, Nick ; Khaw, Kay-Tee ; Gunter, Marc J ; Rinaldi, Sabina ; Tsilidis, Konstantinos K ; Aune, Dagfinn ; Riboli, Elio ; Key, Timothy J. / Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition. I: International Journal of Cancer. 2019 ; Bind 144, Nr. 5. s. 957-966.

Bibtex

@article{884185e740f94fd38712b3cfa9b679ad,
title = "Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition",
abstract = "Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.",
keywords = "EPIC, IGF-I, biomarker, height, insulin-like growth factor I, melanoma, prospective studies, CELLS, METAANALYSIS, CUTANEOUS MELANOMA, INDEX, Prospective Studies, Breast Neoplasms/etiology, Humans, Middle Aged, Male, Melanoma/etiology, Case-Control Studies, Insulin-Like Growth Factor I/metabolism, Adult, Female, Odds Ratio, Europe, Risk Factors, Nutritional Status/physiology, Prostatic Neoplasms/etiology, Aged",
author = "Bradbury, {Kathryn E} and Appleby, {Paul N} and Tipper, {Sarah J} and Travis, {Ruth C} and Allen, {Naomi E} and Marina Kvaskoff and Kim Overvad and Anne Tj{\o}nneland and Jytte Halkjaer and Iris Cevenka and Yahya Mahamat-Saleh and Fabrice Bonnet and Rudolf Kaaks and {Turzanski Fortner}, Ren{\'e}e and Heiner Boeing and Antonia Trichopoulou and {La Vecchia}, Carlo and Stratigos, {Alexander J} and Domenico Palli and Sara Grioni and Giuseppe Matullo and Salvatore Panico and Rosario Tumino and Peeters, {Petra H} and Bas Bueno-de-Mesquita and Reza Ghiasvand and Veier{\o}d, {Marit B} and Elisabete Weiderpass and Catalina Bonet and Elena Molina and Huerta, {Jos{\'e} Mar{\'i}a} and Nerea Larra{\~n}aga and Aurelio Barricarte and Susana Merino and Karolin Isaksson and Tanja Stocks and Ingrid Ljuslinder and Oskar Hemmingsson and Nick Wareham and Kay-Tee Khaw and Gunter, {Marc J} and Sabina Rinaldi and Tsilidis, {Konstantinos K} and Dagfinn Aune and Elio Riboli and Key, {Timothy J}",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = mar,
day = "1",
doi = "10.1002/ijc.31854",
language = "English",
volume = "144",
pages = "957--966",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition

AU - Bradbury, Kathryn E

AU - Appleby, Paul N

AU - Tipper, Sarah J

AU - Travis, Ruth C

AU - Allen, Naomi E

AU - Kvaskoff, Marina

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Halkjaer, Jytte

AU - Cevenka, Iris

AU - Mahamat-Saleh, Yahya

AU - Bonnet, Fabrice

AU - Kaaks, Rudolf

AU - Turzanski Fortner, Renée

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Stratigos, Alexander J

AU - Palli, Domenico

AU - Grioni, Sara

AU - Matullo, Giuseppe

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, Bas

AU - Ghiasvand, Reza

AU - Veierød, Marit B

AU - Weiderpass, Elisabete

AU - Bonet, Catalina

AU - Molina, Elena

AU - Huerta, José María

AU - Larrañaga, Nerea

AU - Barricarte, Aurelio

AU - Merino, Susana

AU - Isaksson, Karolin

AU - Stocks, Tanja

AU - Ljuslinder, Ingrid

AU - Hemmingsson, Oskar

AU - Wareham, Nick

AU - Khaw, Kay-Tee

AU - Gunter, Marc J

AU - Rinaldi, Sabina

AU - Tsilidis, Konstantinos K

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Key, Timothy J

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

AB - Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

KW - EPIC

KW - IGF-I

KW - biomarker

KW - height

KW - insulin-like growth factor I

KW - melanoma

KW - prospective studies

KW - CELLS

KW - METAANALYSIS

KW - CUTANEOUS MELANOMA

KW - INDEX

KW - Prospective Studies

KW - Breast Neoplasms/etiology

KW - Humans

KW - Middle Aged

KW - Male

KW - Melanoma/etiology

KW - Case-Control Studies

KW - Insulin-Like Growth Factor I/metabolism

KW - Adult

KW - Female

KW - Odds Ratio

KW - Europe

KW - Risk Factors

KW - Nutritional Status/physiology

KW - Prostatic Neoplasms/etiology

KW - Aged

U2 - 10.1002/ijc.31854

DO - 10.1002/ijc.31854

M3 - Journal article

C2 - 30191956

VL - 144

SP - 957

EP - 966

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 5

ER -