Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele; K S Hougaard; M Kjølby; M Hokland; G Winther; B Elfving; G Wegener; A L Nielsen; A Larsen; M K Nøhr; S B Pedersen; T Wang; S Lund

doi:10.1038/ijo.2017.136

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele, K S Hougaard, M Kjølby, M Hokland, G Winther, B Elfving, G Wegener, A L Nielsen, A Larsen, M K Nøhr, S B Pedersen, T Wang, S Lund

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

Originalsprog	Engelsk
Tidsskrift	International Journal of Obesity
Vol/bind	41
Nummer	9
Sider (fra-til)	1420-1426
Antal sider	7
ISSN	0307-0565
DOI	https://doi.org/10.1038/ijo.2017.136
Status	Udgivet - 7 jun. 2017

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Dudele, A., Hougaard, K. S., Kjølby, M., Hokland, M., Winther, G., Elfving, B., Wegener, G., Nielsen, A. L., Larsen, A., Nøhr, M. K., Pedersen, S. B., Wang, T., & Lund, S. (2017). Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity, 41(9), 1420-1426. https://doi.org/10.1038/ijo.2017.136

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abstract = "Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.",

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AU - Dudele, A

AU - Hougaard, K S

AU - Kjølby, M

AU - Hokland, M

AU - Winther, G

AU - Elfving, B

AU - Wegener, G

AU - Nielsen, A L

AU - Larsen, A

AU - Nøhr, M K

AU - Pedersen, S B

AU - Wang, T

AU - Lund, S

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N2 - Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

AB - Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

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Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

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