Chitosan nanoparticles containing Physalis alkekengi-L extract: preparation, optimization and their antioxidant activity

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  • Reza Mahmoudi, Yasuj Univ Med Sci, Yasouj University, Cellular & Mol Res Ctr
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  • Maryam Tajali Ardakani, Yasuj Univ Med Sci, Yasouj University, Cellular & Mol Res Ctr
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  • Behnam Hajipour Verdom, Tarbiat Modares Univ, Tarbiat Modares University, Fac Biol Sci, Dept Biophys
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  • Abouzar Bagheri, Mazandaran Univ Med Sci, Mazandaran University Medical Sciences, Dept Clin Biochem & Genet, Fac Med
  • ,
  • Hossein Mohammad-Beigi
  • Farhang Aliakbari, Natl Inst Genet Engn & Biotechnol, Inst Ind & Environm Biotechnol, Bioproc Engn Dept, Sch Med, Dept & Ctr Biotechnol Res
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  • Zeinab Salehpour, Yasuj Univ Med Sci, Yasouj University, Med Plant Res Ctr
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  • Mohsen Alipour, Jahrom Univ Med Sci, Sch Med, Dept Adv Med Sci & Technol
  • ,
  • Sajad Afrouz, Yasuj Univ Med Sci, Yasouj University, Cellular & Mol Res Ctr
  • ,
  • Hassan Bardania, Yasuj Univ Med Sci, Yasouj University, Cellular & Mol Res Ctr

Physalis alkekengi-L is a medicinal herb with a high antioxidant capacity. It is used to treat various diseases. In this study, encapsulation of the hydro-alcoholic extract of P. alkekengi-L into chitosan nanoparticles (CNPs) was optimized by using response surface methodology, and its antioxidant capacity and anticancer activity were investigated. The results of the antioxidant capacity evaluation showed that the antioxidant activity of the chitosan nanoparticles containing extract did not significantly decrease by increasing the time of storage (over a 12 day period) as compared to that of un-encapsulated extracts. In conclusion, CNPs can be used to encapsulate and improve the stability of P. alkekengi-L extract and its antioxidantproperties.

OriginalsprogEngelsk
Artikelnummer131
TidsskriftBulletin of Materials Science
Vol/bind42
Nummer3
Antal sider6
ISSN0250-4707
DOI
StatusUdgivet - jun. 2019

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