Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis

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Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection : a systematic review and meta-analysis. / Bay, Bjørn; Lyngsø, Julie; Hohwü, Lena; Kesmodel, Ulrik Schiøler.

I: B J O G, Bind 126, Nr. 2, 01.2019, s. 158-166.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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@article{ebf548d121cc44c2a34ec1e8f437a363,
title = "Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis",
abstract = "Background Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited. Objective To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception. Search strategy A systematic computerised literature search using the online databases PubMed, Embase, and Scopus. Selection criteria Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons. Data collection and analysis Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale. Main results Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95{\%} confidence interval (95{\%} CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95{\%} CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95{\%} CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height. Conclusions In vitro fertilisation/ICSI was not associated with long-term weight and height.",
keywords = "Assisted reproduction, child development, height, infertility, weight, Body Weight, Humans, Risk Factors, Child, Preschool, Infant, Case-Control Studies, Pregnancy, Body Height, Female, Child Development, Fertilization in Vitro/adverse effects, Sperm Injections, Intracytoplasmic/adverse effects, Child, Infant, Newborn, Pregnancy Outcome, Cohort Studies",
author = "Bj{\o}rn Bay and Julie Lyngs{\o} and Lena Hohw{\"u} and Kesmodel, {Ulrik Schi{\o}ler}",
note = "{\circledC} 2018 Royal College of Obstetricians and Gynaecologists.",
year = "2019",
month = "1",
doi = "10.1111/1471-0528.15456",
language = "English",
volume = "126",
pages = "158--166",
journal = "B J O G",
issn = "1470-0328",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection

T2 - a systematic review and meta-analysis

AU - Bay, Bjørn

AU - Lyngsø, Julie

AU - Hohwü, Lena

AU - Kesmodel, Ulrik Schiøler

N1 - © 2018 Royal College of Obstetricians and Gynaecologists.

PY - 2019/1

Y1 - 2019/1

N2 - Background Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited. Objective To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception. Search strategy A systematic computerised literature search using the online databases PubMed, Embase, and Scopus. Selection criteria Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons. Data collection and analysis Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale. Main results Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height. Conclusions In vitro fertilisation/ICSI was not associated with long-term weight and height.

AB - Background Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long-term follow-up on the growth of these children is limited. Objective To systematically review the literature on post-neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception. Search strategy A systematic computerised literature search using the online databases PubMed, Embase, and Scopus. Selection criteria Cohort or case-control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons. Data collection and analysis Studies were reviewed by at least two authors. Meta-analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle-Ottawa Scale. Main results Twenty studies were included, with 13 of these eligible for meta-analyses. The meta-analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of -160 g; 95% confidence interval (95% CI) -360, 3]. When stratifying by age of child at follow-up, we found a significant lower weight in children aged 0-4 years conceived following IVF/ICSI treatment (MD -180 g; 95% CI -320, -4), but this was no longer significant in children from 5 years of age (MD -160 g; 95% CI -580, 260). The pooled analysis revealed no statistically significant difference in childhood height. Conclusions In vitro fertilisation/ICSI was not associated with long-term weight and height.

KW - Assisted reproduction

KW - child development

KW - height

KW - infertility

KW - weight

KW - Body Weight

KW - Humans

KW - Risk Factors

KW - Child, Preschool

KW - Infant

KW - Case-Control Studies

KW - Pregnancy

KW - Body Height

KW - Female

KW - Child Development

KW - Fertilization in Vitro/adverse effects

KW - Sperm Injections, Intracytoplasmic/adverse effects

KW - Child

KW - Infant, Newborn

KW - Pregnancy Outcome

KW - Cohort Studies

U2 - 10.1111/1471-0528.15456

DO - 10.1111/1471-0528.15456

M3 - Review

C2 - 30168249

VL - 126

SP - 158

EP - 166

JO - B J O G

JF - B J O G

SN - 1470-0328

IS - 2

ER -