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Characterization of hydroxyurea resistance in C. elegans

Publikation: KonferencebidragPosterForskning

  • Jeanette Brejning, Danmark
  • Molekylærbiologisk Institut

The soil nematode Caenorhabditis elegans has become a prominent model organism for studying aging and many age-related diseases. We use C. elegans to study the relationship between cancer and aging. To prevent cancer, cells are equipped with surveillance systems that detect damage and stop cells from dividing. These surveillance systems are collectively called cellular checkpoints. We have found that inactivation of certain checkpoint proteins, including p53, also cause resistance to the chemotherapeutic drug hydroxyurea (HU) that stalls replication. We have found that in C. elegans, HU inhibits ribonucleotide reductase (RNR). RNR is involved in synthesis of deoxyribonucleotide (dNTP) precursors for DNA replication and repair.

Previously we have shown that inactivation of some checkpoint proteins can increase stress resistance and lifespan of C. elegans1. Interestingly, several genes that influence HU resistance also influence lifespan and stress resistance. At least one of these genes seems to function in the S-M checkpoint pathway.

  1.    A. Olsen, M. C. Vantipalli, G. J. Lithgow, Science 312, 1381 (2006).  

OriginalsprogEngelsk
Udgivelsesår2009
StatusUdgivet - 2009
Begivenhed17th International C. elegans Meeting - Los Angeles, USA
Varighed: 24 jun. 200928 jun. 2009
Konferencens nummer: 17

Konference

Konference17th International C. elegans Meeting
Nummer17
LandUSA
ByLos Angeles
Periode24/06/200928/06/2009

    Forskningsområder

  • Checkpoint proteiner, Hydroxyurea resistens

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