Characteristics, interventions and longer-term outcomes of COVID-19 ICU patients in Denmark - a nationwide, observational study

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DOI

  • Nicolai Haase, Københavns Universitet
  • ,
  • Ronni Plovsing, Københavns Universitet
  • ,
  • Steffen Christensen
  • Lone Musaeus Poulsen, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Anne Craveiro Brøchner, Department of Anesthesiology and Intensive Care , Department of Pediatrics, Kolding Hospital, Kolding, Denmark, Ortopædkirurgisk Afdeling, Kolding Sygehus, Kolding
  • ,
  • Bodil Steen Rasmussen, Aalborg Universitet
  • ,
  • Marie Helleberg, Københavns Universitet
  • ,
  • Jens Ulrik Staehr Jensen, Department of Cardiology, Herlev-Gentofte Hospital, University Hospital Copenhagen, Herlev Ringvej 75, Herlev, Denmark.
  • ,
  • Lars Peter Kloster Andersen, Department of Anesthesiology and Intensive Care , Bispebjerg Hospital, Bispebjerg
  • ,
  • Hanna Siegel, Københavns Universitet
  • ,
  • Michael Ibsen, North Zealand Hospital
  • ,
  • Vibeke Jørgensen, Københavns Universitet, Danmark
  • Robert Winding
  • Susanne Iversen, Slagelse Hospital
  • ,
  • Henrik Planck Pedersen, Department of Anesthesiology and Intensive Care , Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Jacob Madsen, Department of Anesthesiology and Intensive Care , Aalborg Psychiatric University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Christoffer Sølling
  • Ricardo Sanchez Garcia, Esbjerg Hospital
  • ,
  • Jens Michelsen, Syddansk Universitet
  • ,
  • Thomas Mohr, Herlev-Gentofte Hospital
  • ,
  • Anne Mannering, Syddansk Universitet
  • ,
  • Ulrick Skipper Espelund, Department of Anesthesiology and Intensive Care , Horsens Fertility Clinic, Horsens Hospital, 8700 Horsens, Denmark.
  • ,
  • Helle Bundgaard
  • ,
  • Lynge Kirkegaard, Aabenraa Hospital
  • ,
  • Margit Smitt, Københavns Universitet
  • ,
  • David Levarett Buck, Holbæk Hospital
  • ,
  • Niels-Erik Ribergaard, Department of Anesthesiology and Intensive Care , Department of Pediatrics, Vendsyssel Hospital Hjørring, Hjørring, Denmark
  • ,
  • Helle Scharling Pedersen, Department of Anesthesiology and Intensive Care , Medical Department, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.
  • ,
  • Birgitte Viebaek Christensen, Department of Anesthesiology and Intensive Care , Pediatric Department, Glostrup Hospital, Glostrup
  • ,
  • Anders Perner, Københavns Universitet

BACKGROUND: Most data on ICU patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter-term follow-up. We present characteristics, interventions and longer-term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded.

METHODS: We identified all patients with SARS-CoV-2 admitted to any Danish ICU from March 10th to May 19th 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay and vital status from patient files. Risk factors for death were analyzed by adjusted Cox regression analysis.

RESULTS: There were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26% and ECMO in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of June 16th 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer and number of co-morbidities.

CONCLUSIONS: In this nationwide, population-based cohort of ICU patients with COVID-19, longer-term survival was high despite high age and substantial use of organ support. Male gender, age and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind65
Nummer1
Sider (fra-til)68-75
Antal sider8
ISSN0001-5172
DOI
StatusUdgivet - jan. 2021

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