TY - JOUR
T1 - Characteristics, interventions and longer-term outcomes of COVID-19 ICU patients in Denmark - a nationwide, observational study
AU - Haase, Nicolai
AU - Plovsing, Ronni
AU - Christensen, Steffen
AU - Poulsen, Lone Musaeus
AU - Brøchner, Anne Craveiro
AU - Rasmussen, Bodil Steen
AU - Helleberg, Marie
AU - Jensen, Jens Ulrik Staehr
AU - Andersen, Lars Peter Kloster
AU - Siegel, Hanna
AU - Ibsen, Michael
AU - Jørgensen, Vibeke
AU - Winding, Robert
AU - Iversen, Susanne
AU - Pedersen, Henrik Planck
AU - Madsen, Jacob
AU - Sølling, Christoffer
AU - Garcia, Ricardo Sanchez
AU - Michelsen, Jens
AU - Mohr, Thomas
AU - Mannering, Anne
AU - Espelund, Ulrick Skipper
AU - Bundgaard, Helle
AU - Kirkegaard, Lynge
AU - Smitt, Margit
AU - Buck, David Levarett
AU - Ribergaard, Niels-Erik
AU - Pedersen, Helle Scharling
AU - Christensen, Birgitte Viebaek
AU - Perner, Anders
N1 - This article is protected by copyright. All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - BACKGROUND: Most data on ICU patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter-term follow-up. We present characteristics, interventions and longer-term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded.METHODS: We identified all patients with SARS-CoV-2 admitted to any Danish ICU from March 10th to May 19th 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay and vital status from patient files. Risk factors for death were analyzed by adjusted Cox regression analysis.RESULTS: There were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26% and ECMO in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of June 16th 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer and number of co-morbidities.CONCLUSIONS: In this nationwide, population-based cohort of ICU patients with COVID-19, longer-term survival was high despite high age and substantial use of organ support. Male gender, age and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death.
AB - BACKGROUND: Most data on ICU patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter-term follow-up. We present characteristics, interventions and longer-term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded.METHODS: We identified all patients with SARS-CoV-2 admitted to any Danish ICU from March 10th to May 19th 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay and vital status from patient files. Risk factors for death were analyzed by adjusted Cox regression analysis.RESULTS: There were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26% and ECMO in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of June 16th 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer and number of co-morbidities.CONCLUSIONS: In this nationwide, population-based cohort of ICU patients with COVID-19, longer-term survival was high despite high age and substantial use of organ support. Male gender, age and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death.
U2 - 10.1111/aas.13701
DO - 10.1111/aas.13701
M3 - Journal article
C2 - 32929715
SN - 0001-5172
VL - 65
SP - 68
EP - 75
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
IS - 1
ER -