Characterisation of the Mammalian Na+, K+-ATPase: Cardiotonic steroids interaction and nanodisc reconstitution

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Jonas Lindholt, Danmark
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 26 jan. 2015

Note vedr. afhandling

During his studies, Jonas Lindholt Gregersen researched the sodium-potassium pump, a protein present in all mammalian cells. The pump is present in the plasma membrane and maintains salt concentrations by transporting sodium out of and potassium into the cell. Jonas Lindholt Gregersen’s studies were bipartite and was about 1) investigation of the sodium-potassium pump’s interaction with cardiotonic steroids, and 2) reconstitution of the sodium-potassium pump in so called nanodiscs, a versatile tool for membrane protein investigation.
The new research findings contribute to a better understanding the structural interaction of the sodium-potassium pump with cardiotonic steroids and provide a means of further investigation using the nanodisc tool, both functionally and structurally.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.


  • Na+/K+-ATPase, Cardiotonic Steroids, Na K ATPase, Nanodisc

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