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Changes in exosomal mirna composition in thyroid cancer cells after prolonged exposure to real microgravity in space

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  • Petra M. Wise, University of Southern California
  • ,
  • Paolo Neviani, University of Southern California
  • ,
  • Stefan Riwaldt, Otto von Guericke University
  • ,
  • Thomas J. Corydon
  • Markus Wehland
  • Markus Braun, German Aerospace Center
  • ,
  • Marcus Krüger, Otto von Guericke University
  • ,
  • Manfred Infanger, Otto von Guericke University
  • ,
  • Daniela Grimm

As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, research-ing the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell–cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.

OriginalsprogEngelsk
Artikelnummer12841
TidsskriftInternational Journal of Molecular Sciences
Vol/bind22
Nummer23
Antal sider24
ISSN1661-6596
DOI
StatusUdgivet - nov. 2021

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