Projekter pr. år
Abstract
BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation.
RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions.
CONCLUSION: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | e4721 |
| Tidsskrift | Medicine (Baltimore) |
| Vol/bind | 95 |
| Nummer | 37 |
| Sider (fra-til) | e4721 |
| ISSN | 0025-7974 |
| DOI | |
| Status | Udgivet - sep. 2016 |
Fingeraftryk
Dyk ned i forskningsemnerne om 'Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report'. Sammen danner de et unikt fingeraftryk.-
The Danish Mole Project
Sunde, L. (Deltager), Bolund, L. (Deltager), Niemann, I. (Deltager), Fisher, R. A. (Samarbejdspartner) & Slim, R. (Deltager)
01/04/1986 → …
Projekter: Projekt › Forskning
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Cirkulerende DNA og cirkulerende celler i diagnostik af maligne trofoblastsygdomme
Sunde, L. (Deltager), Kristiansen, M. K. (Deltager), Niemann, I. (Deltager), Lindegaard, J. C. (Deltager), Lildballe, D. L. (Deltager), Singh, R. (Deltager), Schelde, P. (Samarbejdspartner) & Hatt, L. (Deltager)
01/01/2015 → 01/06/2023
Projekter: Projekt › Forskning