CEACAM18 as candidate for the Holstein calving QTL on BTA18

Publikation: KonferencebidragPaperForskningpeer review

Dokumenter

  • Paper

    Accepteret manuskript, 245 KB, PDF-dokument

Links

  • Xiaowei Mao, Danmark
  • Naveen Kumar Kadri, Danmark
  • DirkJan de Koning, Swedish University of Agricultural Sciences, Uppsala, Sweden, Sverige
  • Goutam Sahana
  • Bernt Guldbrandtsen
A genome-wide association study of Nordic Holstein cattle SNP chip genotypes and imputed next generation sequencing (NGS) variants identified carcinoembryonic antigen-related cell adhesion molecule 18 (CEACAm 18) on BTa 18 as the gene most highly significantly associated with direct calving traits. Phenotypes used were estimated breeding values (EBV) for six direct calving traits and one compound index trait. A SNP by SNP mixed model approach was first applied using HD genotypes. Haplotypes in the significant region were fitted in a mixed model. Finally, NGS variants in the significant region were utilized to precisely locate causative mutations. Results identified 21 QTL regions associated with one or more calving traits on 16 autosomes. These findings contribute to an improved understanding of the genetic architecture of the calving traits. They may help in improving calving performance in dairy breeding programs
OriginalsprogEngelsk
Udgivelsesår17 aug. 2014
Antal sider3
StatusUdgivet - 17 aug. 2014
Begivenhed10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Varighed: 17 aug. 201422 aug. 2014
Konferencens nummer: 10th

Konference

Konference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Nummer10th
LokationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
LandCanada
ByVancouver
Periode17/08/201422/08/2014

Se relationer på Aarhus Universitet Citationsformater

Aktiviteter

Download-statistik

Ingen data tilgængelig

ID: 81362198