Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells. / Hansen, Aida Solhøj; Biltoft, Mette; Bundgaard, Bettina; Bohn, Anja Bille; Møller, Bjarne Kuno; Höllsberg, Per Brøndsted.
I: Cytokine, Bind 113, 01.2019, s. 466-469.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells
AU - Hansen, Aida Solhøj
AU - Biltoft, Mette
AU - Bundgaard, Bettina
AU - Bohn, Anja Bille
AU - Møller, Bjarne Kuno
AU - Höllsberg, Per Brøndsted
PY - 2019/1
Y1 - 2019/1
N2 - CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.
AB - CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.
KW - CD46
KW - CXCL-10
KW - Monocyte-derived dendritic cells
KW - Monocytes
U2 - 10.1016/j.cyto.2018.06.030
DO - 10.1016/j.cyto.2018.06.030
M3 - Journal article
C2 - 29980471
VL - 113
SP - 466
EP - 469
JO - Cytokine
JF - Cytokine
SN - 1043-4666
ER -