CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells

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CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells. / Hansen, Aida Solhøj; Biltoft, Mette; Bundgaard, Bettina; Bohn, Anja Bille; Møller, Bjarne Kuno; Höllsberg, Per Brøndsted.

I: Cytokine, Bind 113, 01.2019, s. 466-469.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{01dbebaf499046148cdc39eaa2525373,
title = "CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells",
abstract = "CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.",
keywords = "CD46, CXCL-10, Monocyte-derived dendritic cells, Monocytes",
author = "Hansen, {Aida Solh{\o}j} and Mette Biltoft and Bettina Bundgaard and Bohn, {Anja Bille} and M{\o}ller, {Bjarne Kuno} and H{\"o}llsberg, {Per Br{\o}ndsted}",
year = "2019",
month = jan,
doi = "10.1016/j.cyto.2018.06.030",
language = "English",
volume = "113",
pages = "466--469",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells

AU - Hansen, Aida Solhøj

AU - Biltoft, Mette

AU - Bundgaard, Bettina

AU - Bohn, Anja Bille

AU - Møller, Bjarne Kuno

AU - Höllsberg, Per Brøndsted

PY - 2019/1

Y1 - 2019/1

N2 - CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.

AB - CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.

KW - CD46

KW - CXCL-10

KW - Monocyte-derived dendritic cells

KW - Monocytes

U2 - 10.1016/j.cyto.2018.06.030

DO - 10.1016/j.cyto.2018.06.030

M3 - Journal article

C2 - 29980471

VL - 113

SP - 466

EP - 469

JO - Cytokine

JF - Cytokine

SN - 1043-4666

ER -