Catheter-based therapies in acute pulmonary embolism

Jacob Schultz; Asger Andersen; Christopher Kabrhel; Jens Erik Nielsen-Kudsk

doi:10.4244/EIJ-D-17-00437

Catheter-based therapies in acute pulmonary embolism

Jacob Schultz, Asger Andersen, Christopher Kabrhel, Jens Erik Nielsen-Kudsk

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

20 Citationer (Scopus)

Abstract

Aims: We aimed to provide a systematic review of catheter-based therapies in acute pulmonary embolism (PE). Methods and results: Studies published in peer-reviewed journals before February 2017 were included and categorised according to the mechanism of thrombus removal: fragmentation, rheolytic therapy, aspiration or catheter-directed thrombolysis. Strengths, challenges and the level of evidence of each device were evaluated. We found 16 different catheter-based therapies for acute PE, all but one being used off-label. The majority of procedures involve catheter-directed thrombolysis. Aspiration therapy shows promise, but limited data are available. Rheolytic therapy should be used with caution, if at all, due to the high number of associated complications. Conclusions: Catheter-based therapies show promise as a treatment for acute PE, though evidence is lacking. Further research into the efficacy and safety of devices is needed.

Originalsprog	Engelsk
Tidsskrift	EuroIntervention
Vol/bind	13
Nummer	14
Sider (fra-til)	1721-1727
Antal sider	7
ISSN	1774-024X
DOI	https://doi.org/10.4244/EIJ-D-17-00437
Status	Udgivet - 28 feb. 2018

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abstract = "Aims: We aimed to provide a systematic review of catheter-based therapies in acute pulmonary embolism (PE). Methods and results: Studies published in peer-reviewed journals before February 2017 were included and categorised according to the mechanism of thrombus removal: fragmentation, rheolytic therapy, aspiration or catheter-directed thrombolysis. Strengths, challenges and the level of evidence of each device were evaluated. We found 16 different catheter-based therapies for acute PE, all but one being used off-label. The majority of procedures involve catheter-directed thrombolysis. Aspiration therapy shows promise, but limited data are available. Rheolytic therapy should be used with caution, if at all, due to the high number of associated complications. Conclusions: Catheter-based therapies show promise as a treatment for acute PE, though evidence is lacking. Further research into the efficacy and safety of devices is needed.",

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N2 - Aims: We aimed to provide a systematic review of catheter-based therapies in acute pulmonary embolism (PE). Methods and results: Studies published in peer-reviewed journals before February 2017 were included and categorised according to the mechanism of thrombus removal: fragmentation, rheolytic therapy, aspiration or catheter-directed thrombolysis. Strengths, challenges and the level of evidence of each device were evaluated. We found 16 different catheter-based therapies for acute PE, all but one being used off-label. The majority of procedures involve catheter-directed thrombolysis. Aspiration therapy shows promise, but limited data are available. Rheolytic therapy should be used with caution, if at all, due to the high number of associated complications. Conclusions: Catheter-based therapies show promise as a treatment for acute PE, though evidence is lacking. Further research into the efficacy and safety of devices is needed.

AB - Aims: We aimed to provide a systematic review of catheter-based therapies in acute pulmonary embolism (PE). Methods and results: Studies published in peer-reviewed journals before February 2017 were included and categorised according to the mechanism of thrombus removal: fragmentation, rheolytic therapy, aspiration or catheter-directed thrombolysis. Strengths, challenges and the level of evidence of each device were evaluated. We found 16 different catheter-based therapies for acute PE, all but one being used off-label. The majority of procedures involve catheter-directed thrombolysis. Aspiration therapy shows promise, but limited data are available. Rheolytic therapy should be used with caution, if at all, due to the high number of associated complications. Conclusions: Catheter-based therapies show promise as a treatment for acute PE, though evidence is lacking. Further research into the efficacy and safety of devices is needed.

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Catheter-based therapies in acute pulmonary embolism

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