Catalytic Enantioselective [10+4] Cycloadditions

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The first peri- and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron-deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields, reflecting a robust higher-order cycloaddition. Experimental and computational investigations support a kinetic distribution of intermediate rotamers dictating the enantioselectivity, which relies heavily on additive effects.

OriginalsprogEngelsk
TidsskriftAngewandte Chemie - International Edition
Vol/bind57
Nummer40
Sider (fra-til)13182-13186
Antal sider5
ISSN1433-7851
DOI
StatusUdgivet - 1 okt. 2018

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