TY - JOUR
T1 - Case report
T2 - Transcatheter aortic valve replacement in a large bicuspid anatomy using the XL-Myval 32 mm
AU - Elkoumy, Ahmed
AU - Terkelsen, Christian J.
AU - Abdelshafy, Mahmoud
AU - Ellert-Gregersen, Julia
AU - Elzomor, Hesham
AU - Thim, Troels
AU - Serruys, Patrick W.
AU - Soliman, Osama
AU - Nissen, Henrik
N1 - Publisher Copyright:
Copyright © 2022 Elkoumy, Terkelsen, Abdelshafy, Ellert-Gregersen, Elzomor, Thim, Serruys, Soliman and Nissen.
PY - 2022/11
Y1 - 2022/11
N2 - Transcatheter aortic valve replacement (TAVR) is a recommended intervention for selected population with severe aortic stenosis (AS). Bicuspid aortic valve (BAV) anatomy has been categorized as an unfavorable anatomy for TAVR due to multiple considerations as exclusion from randomized trials in addition to the challenging and unpredictable anatomy. The anatomical constraints of BAV include the large anatomy of the annulus, sinus of Valsalva, and aorta (aortopathy), in addition to significant calcifications of the device landing zone. Most commercial transcatheter heart valves (THV) have upper dimension limits of the annulus and area in which the device can be implanted safely without significant oversizing. Myval-XL THVs (Meril Life Sciences Pvt. Ltd., India) are balloon-expandable valves (BEV) that have been developed with two new sizes, 30.5 and 32 mm, aiming to treat patients with large annulus dimensions and that exceed the upper limit of an ordinary device’s sizing matrix. This case series report describes TAVR using the XL-Myval 32 mm THV in three European patients with symptomatic severe bicuspid aortic stenosis with significant calcifications and large annular dimensions exceeding the limits of the other THVs.
AB - Transcatheter aortic valve replacement (TAVR) is a recommended intervention for selected population with severe aortic stenosis (AS). Bicuspid aortic valve (BAV) anatomy has been categorized as an unfavorable anatomy for TAVR due to multiple considerations as exclusion from randomized trials in addition to the challenging and unpredictable anatomy. The anatomical constraints of BAV include the large anatomy of the annulus, sinus of Valsalva, and aorta (aortopathy), in addition to significant calcifications of the device landing zone. Most commercial transcatheter heart valves (THV) have upper dimension limits of the annulus and area in which the device can be implanted safely without significant oversizing. Myval-XL THVs (Meril Life Sciences Pvt. Ltd., India) are balloon-expandable valves (BEV) that have been developed with two new sizes, 30.5 and 32 mm, aiming to treat patients with large annulus dimensions and that exceed the upper limit of an ordinary device’s sizing matrix. This case series report describes TAVR using the XL-Myval 32 mm THV in three European patients with symptomatic severe bicuspid aortic stenosis with significant calcifications and large annular dimensions exceeding the limits of the other THVs.
KW - BAV
KW - bicuspid aortic valve
KW - large annulus
KW - Myval-XL
KW - transcatheter aortic valve replacement
UR - http://www.scopus.com/inward/record.url?scp=85143845073&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.1045280
DO - 10.3389/fcvm.2022.1045280
M3 - Journal article
C2 - 36505358
AN - SCOPUS:85143845073
SN - 2297-055X
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 1045280
ER -