CarbonylDB: A curated data-resource of protein carbonylation sites

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  • R. Shyama Prasad Rao, Yenepoya University
  • ,
  • Ning Zhang, University of Missouri-Columbia
  • ,
  • Dong Xu, University of Missouri-Columbia
  • ,
  • Ian Max Møller

Motivation: Oxidative stress and protein damage have been associated with over 200 human ailments including cancer, stroke, neuro-degenerative diseases and aging. Protein carbonylation, a chemically diverse oxidative post-translational modification, is widely considered as the biomarker for oxidative stress and protein damage. Despite their importance and extensive studies, no database/ resource on carbonylated proteins/sites exists. As such information is very useful to research in biology/medicine, we have manually curated a data-resource (CarbonylDB) of experimentallyconfirmed carbonylated proteins/sites. Results: The CarbonylDB currently contains 1495 carbonylated proteins and 3781 sites from 21 species, with human, rat and yeast as the top three species. We have made further analyses of these carbonylated proteins/sites and presented their occurrence and occupancy patterns. Carbonylation site data on serum albumin, in particular, provides a fine model system to understand the dynamics of oxidative protein modifications/damage.

OriginalsprogEngelsk
TidsskriftBioinformatics
Vol/bind34
Nummer14
Sider (fra-til)2518-2520
Antal sider3
ISSN1367-4803
DOI
StatusUdgivet - 1 jan. 2018

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