Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » Capillary dysfunction correlates with cortical amyloid lo...

Om AU

Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

Alterations in cerebral perfusion is increasingly considered to play a crucial role in Alzheimer’s disease (AD) and together with accumulated amyloid-β, deficiencies in the brain microvascular circulation may result in local hypoxia. Here, we studied alterations in cerebral circulation and the correlation between amyloid-β load and cerebral perfusion in prodromal AD (pAD). Using dynamic susceptibility contrast MRI and PET, we evaluated cerebral perfusion and amyloid-β levels in 19 individuals with mild cognitive impairment (MCI) and high amyloid-β load (pAD-MCI), 13 MCI individuals without AD pathology and 21 healthy controls. The pAD-MCI group showed significantly lower microvascular blood flow and significantly higher heterogeneity of microvascular blood transit times (p < 0.01) compared with the other 2 groups. Additionally, in the pAD-MCI group raised amyloid-β levels correlated with decreased microvascular blood flow and increased heterogeneity of microvascular blood flow in frontal and temporal areas (p < 0.01). These results indicate a close connection between levels of amyloid-β deposition and brain microvascular perfusion in pAD. A vicious cycle may be established where amyloid-β load and deficiencies in brain perfusion may reinforce each other.
OriginalsprogEngelsk
TidsskriftNeurobiology of Aging
Vol/bind123
Sider (fra-til)1-9
Antal sider9
ISSN0197-4580
DOI
StatusUdgivet - mar. 2023

    Forskningsområder

  • Alzheimer’s disease, Capillary, Amyloid-β, Mild cognitive impairment, Perfusion MRI, PiB PET, Blood flow

Se relationer på Aarhus Universitet Citationsformater

ID: 300735519