Can a Charged Surfactant Unfold an Uncharged Protein?

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Does sodium dodecyl sulfate (SDS) denature proteins through electrostatic SDS-protein interactions? We show that a protein completely lacking charged side chains is unfolded by SDS in a manner similar to charged proteins, revealing that formal protein charges are not required for SDS-induced protein unfolding or binding.

OriginalsprogEngelsk
TidsskriftBiophysical Journal
Vol/bind115
Nummer11
Sider (fra-til)2081-2086
ISSN0006-3495
DOI
StatusUdgivet - 4 dec. 2018

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Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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