Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

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Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. / Østergaard, John Rosendahl; Ostergaard, K; Andersson, K.E.; Sommer, L.

I: Acta pharmacologica et toxicologica, Bind 46 Suppl 1, 1980, s. 12-9.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Østergaard, JR, Ostergaard, K, Andersson, KE & Sommer, L 1980, 'Calcium antagonistic effects of terodiline in rabbit aorta and human uterus', Acta pharmacologica et toxicologica, bind 46 Suppl 1, s. 12-9.

APA

Østergaard, J. R., Ostergaard, K., Andersson, K. E., & Sommer, L. (1980). Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. Acta pharmacologica et toxicologica, 46 Suppl 1, 12-9.

CBE

Østergaard JR, Ostergaard K, Andersson KE, Sommer L. 1980. Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. Acta pharmacologica et toxicologica. 46 Suppl 1:12-9.

MLA

Vancouver

Østergaard JR, Ostergaard K, Andersson KE, Sommer L. Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. Acta pharmacologica et toxicologica. 1980;46 Suppl 1:12-9.

Author

Østergaard, John Rosendahl ; Ostergaard, K ; Andersson, K.E. ; Sommer, L. / Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. I: Acta pharmacologica et toxicologica. 1980 ; Bind 46 Suppl 1. s. 12-9.

Bibtex

@article{746247e0ede311dd8f9a000ea68e967b,
title = "Calcium antagonistic effects of terodiline in rabbit aorta and human uterus",
abstract = "The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.",
keywords = "Adult, Animals, Aorta, Thoracic, Butylamines, Calcium, Dose-Response Relationship, Drug, Female, Humans, Male, Muscle, Smooth, Myometrium, Parasympatholytics, Pregnancy, Rabbits, Uterus",
author = "{\O}stergaard, {John Rosendahl} and K Ostergaard and K.E. Andersson and L Sommer",
year = "1980",
language = "English",
volume = "46 Suppl 1",
pages = "12--9",
journal = "Acta pharmacologica et toxicologica",
issn = "0001-6683",
publisher = "Munksgaard International Publishers",

}

RIS

TY - JOUR

T1 - Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

AU - Østergaard, John Rosendahl

AU - Ostergaard, K

AU - Andersson, K.E.

AU - Sommer, L

PY - 1980

Y1 - 1980

N2 - The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.

AB - The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.

KW - Adult

KW - Animals

KW - Aorta, Thoracic

KW - Butylamines

KW - Calcium

KW - Dose-Response Relationship, Drug

KW - Female

KW - Humans

KW - Male

KW - Muscle, Smooth

KW - Myometrium

KW - Parasympatholytics

KW - Pregnancy

KW - Rabbits

KW - Uterus

M3 - Journal article

C2 - 7386217

VL - 46 Suppl 1

SP - 12

EP - 19

JO - Acta pharmacologica et toxicologica

JF - Acta pharmacologica et toxicologica

SN - 0001-6683

ER -