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Calcium antagonistic effects of terodiline in rabbit aorta and human uterus. / Østergaard, John Rosendahl; Ostergaard, K; Andersson, K.E.; Sommer, L.
I: Acta pharmacologica et toxicologica, Bind 46 Suppl 1, 1980, s. 12-9.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Calcium antagonistic effects of terodiline in rabbit aorta and human uterus
AU - Østergaard, John Rosendahl
AU - Ostergaard, K
AU - Andersson, K.E.
AU - Sommer, L
PY - 1980
Y1 - 1980
N2 - The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.
AB - The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.
KW - Adult
KW - Animals
KW - Aorta, Thoracic
KW - Butylamines
KW - Calcium
KW - Dose-Response Relationship, Drug
KW - Female
KW - Humans
KW - Male
KW - Muscle, Smooth
KW - Myometrium
KW - Parasympatholytics
KW - Pregnancy
KW - Rabbits
KW - Uterus
M3 - Journal article
C2 - 7386217
VL - 46 Suppl 1
SP - 12
EP - 19
JO - Acta pharmacologica et toxicologica
JF - Acta pharmacologica et toxicologica
SN - 0001-6683
ER -