Breast feeding and timing of puberty in boys and girls: A nationwide cohort study

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Breast feeding and timing of puberty in boys and girls: A nationwide cohort study. / Hvidt, Julie Jessen; Brix, Nis; Ernst, Andreas; Lauridsen, Lea Lykke Braskhøj; Ramlau-Hansen, Cecilia.

I: Paediatric and Perinatal Epidemiology, Bind 35, Nr. 5, 09.2021, s. 578-589.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Hvidt, Julie Jessen o.a.. "Breast feeding and timing of puberty in boys and girls: A nationwide cohort study". Paediatric and Perinatal Epidemiology. 2021, 35(5). 578-589. https://doi.org/10.1111/ppe.12767

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@article{7dc3b2f1d5f14ce9b0cb2b625be8de9a,
title = "Breast feeding and timing of puberty in boys and girls: A nationwide cohort study",
abstract = "Background: Breast feeding has been associated with improved infant health, but its impact on pubertal timing remains uncertain, particularly in boys. Objective: The objective of this study was to investigate the association between duration of breast feeding and pubertal timing in boys and girls. Methods: This population-based cohort study included 13 511 boys and girls from the Puberty Cohort nested within the Danish National Birth Cohort. The children gave half-yearly, self-reported information on pubertal development through questionnaires (Tanner stages, age at menarche, first ejaculation, voice break, axillary hair growth, and acne). Information on breast feeding was provided by the mothers when the children were 6 months of age. We estimated mean differences (in months) in age at attaining each pubertal marker and for overall timing of puberty (combined estimate) for every additional month of exclusive breast feeding. Furthermore, we estimated differences in pubertal age when comparing children never exclusively breastfed and exclusively breastfed <4 months using children exclusively breastfed ≥4 months as reference. In sub-analyses, we further adjusted for infant weight gain and childhood BMI at 7 years to investigate whether these variables mediated the association. Results: Boys tended to reach pubertal markers later for every additional month of exclusive breast feeding (combined estimate: 0.2 (95% confidence interval [CI] 0.0, 0.4 months). Never exclusively breastfed boys reached pubertal markers earlier than the boys exclusively breastfed ≥4 months (combined estimate: −4.1 (95% CI −6.7, −1.6) months). Boys exclusively breastfed <4 months also reached pubertal markers earlier than those never exclusively breastfed but with smaller differences. In girls, duration of breast feeding was not associated with pubertal development. When including infant weight gain or childhood BMI, the results remained essentially unchanged. Conclusions: Shorter duration of exclusive breast feeding was associated with earlier pubertal development in boys but not in girls.",
keywords = "breast feeding, pubertal timing, puberty, tanner stages",
author = "Hvidt, {Julie Jessen} and Nis Brix and Andreas Ernst and Lauridsen, {Lea Lykke Braskh{\o}j} and Cecilia Ramlau-Hansen",
year = "2021",
month = sep,
doi = "10.1111/ppe.12767",
language = "English",
volume = "35",
pages = "578--589",
journal = "Paediatric and Perinatal Epidemiology (Online)",
issn = "1365-3016",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - Breast feeding and timing of puberty in boys and girls: A nationwide cohort study

AU - Hvidt, Julie Jessen

AU - Brix, Nis

AU - Ernst, Andreas

AU - Lauridsen, Lea Lykke Braskhøj

AU - Ramlau-Hansen, Cecilia

PY - 2021/9

Y1 - 2021/9

N2 - Background: Breast feeding has been associated with improved infant health, but its impact on pubertal timing remains uncertain, particularly in boys. Objective: The objective of this study was to investigate the association between duration of breast feeding and pubertal timing in boys and girls. Methods: This population-based cohort study included 13 511 boys and girls from the Puberty Cohort nested within the Danish National Birth Cohort. The children gave half-yearly, self-reported information on pubertal development through questionnaires (Tanner stages, age at menarche, first ejaculation, voice break, axillary hair growth, and acne). Information on breast feeding was provided by the mothers when the children were 6 months of age. We estimated mean differences (in months) in age at attaining each pubertal marker and for overall timing of puberty (combined estimate) for every additional month of exclusive breast feeding. Furthermore, we estimated differences in pubertal age when comparing children never exclusively breastfed and exclusively breastfed <4 months using children exclusively breastfed ≥4 months as reference. In sub-analyses, we further adjusted for infant weight gain and childhood BMI at 7 years to investigate whether these variables mediated the association. Results: Boys tended to reach pubertal markers later for every additional month of exclusive breast feeding (combined estimate: 0.2 (95% confidence interval [CI] 0.0, 0.4 months). Never exclusively breastfed boys reached pubertal markers earlier than the boys exclusively breastfed ≥4 months (combined estimate: −4.1 (95% CI −6.7, −1.6) months). Boys exclusively breastfed <4 months also reached pubertal markers earlier than those never exclusively breastfed but with smaller differences. In girls, duration of breast feeding was not associated with pubertal development. When including infant weight gain or childhood BMI, the results remained essentially unchanged. Conclusions: Shorter duration of exclusive breast feeding was associated with earlier pubertal development in boys but not in girls.

AB - Background: Breast feeding has been associated with improved infant health, but its impact on pubertal timing remains uncertain, particularly in boys. Objective: The objective of this study was to investigate the association between duration of breast feeding and pubertal timing in boys and girls. Methods: This population-based cohort study included 13 511 boys and girls from the Puberty Cohort nested within the Danish National Birth Cohort. The children gave half-yearly, self-reported information on pubertal development through questionnaires (Tanner stages, age at menarche, first ejaculation, voice break, axillary hair growth, and acne). Information on breast feeding was provided by the mothers when the children were 6 months of age. We estimated mean differences (in months) in age at attaining each pubertal marker and for overall timing of puberty (combined estimate) for every additional month of exclusive breast feeding. Furthermore, we estimated differences in pubertal age when comparing children never exclusively breastfed and exclusively breastfed <4 months using children exclusively breastfed ≥4 months as reference. In sub-analyses, we further adjusted for infant weight gain and childhood BMI at 7 years to investigate whether these variables mediated the association. Results: Boys tended to reach pubertal markers later for every additional month of exclusive breast feeding (combined estimate: 0.2 (95% confidence interval [CI] 0.0, 0.4 months). Never exclusively breastfed boys reached pubertal markers earlier than the boys exclusively breastfed ≥4 months (combined estimate: −4.1 (95% CI −6.7, −1.6) months). Boys exclusively breastfed <4 months also reached pubertal markers earlier than those never exclusively breastfed but with smaller differences. In girls, duration of breast feeding was not associated with pubertal development. When including infant weight gain or childhood BMI, the results remained essentially unchanged. Conclusions: Shorter duration of exclusive breast feeding was associated with earlier pubertal development in boys but not in girls.

KW - breast feeding

KW - pubertal timing

KW - puberty

KW - tanner stages

U2 - 10.1111/ppe.12767

DO - 10.1111/ppe.12767

M3 - Journal article

C2 - 34080724

VL - 35

SP - 578

EP - 589

JO - Paediatric and Perinatal Epidemiology (Online)

JF - Paediatric and Perinatal Epidemiology (Online)

SN - 1365-3016

IS - 5

ER -