Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » Breast Cancer Incidence in Relation to Long-Term Low-Leve...

Om AU

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Ulla Arthur Hvidtfeldt, Kræftens Bekæmpelse
    • ,
  • Jie Chen, Utrecht University
    • ,
  • Sophia Rodopoulou, University of Athens
    • ,
  • Maciej Strak, Utrecht University, National Institute for Public Health and the Environment (RIVM)
    • ,
  • Kees de Hoogh, Swiss Tropical and Public Health Institute
    • ,
  • Zorana J. Andersen, Københavns Universitet
    • ,
  • Tom Bellander, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden
    • ,
  • Jørgen Brandt
  • Daniela Fecht, MRC Centre for Environment and Health
    • ,
  • Francesco Forastiere, Lazio Regional Health Service, Imperial College London
    • ,
  • John Gulliver, MRC Centre for Environment and Health, University of Leicester
    • ,
  • Ole Hertel
  • Barbara H. Hoffmann, Heinrich Heine University Düsseldorf
    • ,
  • Klea Katsouyanni, University of Athens, MRC Centre for Environment and Health
    • ,
  • Matthias Ketzel
  • Boel Brynedal, Karolinska Institutet
    • ,
  • Karin Leander, Karolinska Institutet
    • ,
  • Petter L.S. Ljungman, Karolinska Institutet
    • ,
  • Patrik K.E. Magnusson, Karolinska Institutet
    • ,
  • Gabriele Nagel, Ulm University
    • ,
  • Göran Pershagen, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden
    • ,
  • Debora Rizzuto, Karolinska Institutet, Karolinska Institutet and Stockholm University and The Stockholm Gerontology Research Center
    • ,
  • Marie Christine Boutron-Ruault, Universite Paris-Saclay
    • ,
  • Evangelia Samoli, University of Athens
    • ,
  • Rina So, Københavns Universitet
    • ,
  • Massimo Stafoggia, Karolinska Institutet, Lazio Regional Health Service
    • ,
  • Anne Tjønneland, Kræftens Bekæmpelse, Københavns Universitet
    • ,
  • Roel Vermeulen, Utrecht University
    • ,
  • W. M.Monique Verschuren, National Institute for Public Health and the Environment (RIVM), Utrecht University
    • ,
  • Gudrun Weinmayr, Ulm University
    • ,
  • Kathrin Wolf, Helmholtz Zentrum München - German Research Center for Environmental Health
    • ,
  • Jiawei Zhang, Københavns Universitet
    • ,
  • Emanuel Zitt, Agency for Preventive and Social Medicine, LKH Feldkirch
    • ,
  • Bert Brunekreef, Utrecht University
    • ,
  • Gerard Hoek, Utrecht University
    • ,
  • Ole Raaschou-Nielsen

BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

OriginalsprogEngelsk
TidsskriftCancer Epidemiology, Biomarkers & Prevention
Vol/bind32
Nummer1
Sider (fra-til)105-113
Antal sider9
ISSN1538-7755
DOI
StatusUdgivet - jan. 2023

Bibliografisk note

Publisher Copyright:
©2022 American Association for Cancer Research.

Se relationer på Aarhus Universitet Citationsformater

ID: 311391406