Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment

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Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment. / Hedebo Hansen, Thomas; Guldberg, Rikke; Meinert, Mette.

I: European Journal of Obstetrics & Gynecology and Reproductive Biology, Bind 234, Nr. March, 2019, s. 6-9.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hedebo Hansen, T, Guldberg, R & Meinert, M 2019, 'Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment', European Journal of Obstetrics & Gynecology and Reproductive Biology, bind 234, nr. March, s. 6-9. https://doi.org/10.1016/j.ejogrb.2018.12.013

APA

Hedebo Hansen, T., Guldberg, R., & Meinert, M. (2019). Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment. European Journal of Obstetrics & Gynecology and Reproductive Biology, 234(March), 6-9. https://doi.org/10.1016/j.ejogrb.2018.12.013

CBE

Hedebo Hansen T, Guldberg R, Meinert M. 2019. Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment. European Journal of Obstetrics & Gynecology and Reproductive Biology. 234(March):6-9. https://doi.org/10.1016/j.ejogrb.2018.12.013

MLA

Hedebo Hansen, Thomas, Rikke Guldberg, og Mette Meinert. "Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment". European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019, 234(March). 6-9. https://doi.org/10.1016/j.ejogrb.2018.12.013

Vancouver

Hedebo Hansen T, Guldberg R, Meinert M. Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019;234(March):6-9. https://doi.org/10.1016/j.ejogrb.2018.12.013

Author

Hedebo Hansen, Thomas ; Guldberg, Rikke ; Meinert, Mette. / Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment. I: European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019 ; Bind 234, Nr. March. s. 6-9.

Bibtex

@article{a688bae1f66c422ea63622c433910641,
title = "Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment",
abstract = "INTRODUCTION: We wanted to evaluate the efficacy of botulinum toxin type A (botulinum toxin) treatment on vulvodynia refractory to conventional treatment.MATERIAL AND METHODS: A follow-up study on botulinum toxin treatment was conducted at Aarhus University Hospital (n = 109). Seventy-nine completed the follow-up. The women included had localized provoked vulvodynia, refractory to first line treatment and were treated with 100*I.E. botulinum toxin electromyography (EMG) guided in the musculus levator ani in the period from March 2012 to May 2015(1). The outcome measures were: Dyspareunia, Negative Interference in Quality of Life (NIQL) and cotton swab test all rated on the numerical rating scale (NRS) and active vitae sexualis. Follow-up was conducted at six months.RESULTS: The women experienced significant improvements on, dyspareunia, which decreased to 5.82 from 7.82 (p < 0.01), NIQL to 6.19 from 7.88 (p < 0.01) and the cotton swab test to 5.50 from 6.81 (p < 0.01). No significant effect on Active Vitae Sexualis was found (p = 0.25).CONCLUSION: Women injected with 100*I.E. botulinum toxin EMG guided, diagnosed with localized provoked vulvodynia refractory to conventional non invasive treatment, had a reduction in dyspareunia and improved quality of life. Injection of botulinum toxin had no significant effect on vitae sexualis. Randomized controlled trials are, however, much needed.",
keywords = "Botulinum toxins, Dyspareunia, Female, NRS, Pelvic pain, Sexuality, Type A, Vulvodynia",
author = "{Hedebo Hansen}, Thomas and Rikke Guldberg and Mette Meinert",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
doi = "10.1016/j.ejogrb.2018.12.013",
language = "English",
volume = "234",
pages = "6--9",
journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd.",
number = "March",

}

RIS

TY - JOUR

T1 - Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment

AU - Hedebo Hansen, Thomas

AU - Guldberg, Rikke

AU - Meinert, Mette

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019

Y1 - 2019

N2 - INTRODUCTION: We wanted to evaluate the efficacy of botulinum toxin type A (botulinum toxin) treatment on vulvodynia refractory to conventional treatment.MATERIAL AND METHODS: A follow-up study on botulinum toxin treatment was conducted at Aarhus University Hospital (n = 109). Seventy-nine completed the follow-up. The women included had localized provoked vulvodynia, refractory to first line treatment and were treated with 100*I.E. botulinum toxin electromyography (EMG) guided in the musculus levator ani in the period from March 2012 to May 2015(1). The outcome measures were: Dyspareunia, Negative Interference in Quality of Life (NIQL) and cotton swab test all rated on the numerical rating scale (NRS) and active vitae sexualis. Follow-up was conducted at six months.RESULTS: The women experienced significant improvements on, dyspareunia, which decreased to 5.82 from 7.82 (p < 0.01), NIQL to 6.19 from 7.88 (p < 0.01) and the cotton swab test to 5.50 from 6.81 (p < 0.01). No significant effect on Active Vitae Sexualis was found (p = 0.25).CONCLUSION: Women injected with 100*I.E. botulinum toxin EMG guided, diagnosed with localized provoked vulvodynia refractory to conventional non invasive treatment, had a reduction in dyspareunia and improved quality of life. Injection of botulinum toxin had no significant effect on vitae sexualis. Randomized controlled trials are, however, much needed.

AB - INTRODUCTION: We wanted to evaluate the efficacy of botulinum toxin type A (botulinum toxin) treatment on vulvodynia refractory to conventional treatment.MATERIAL AND METHODS: A follow-up study on botulinum toxin treatment was conducted at Aarhus University Hospital (n = 109). Seventy-nine completed the follow-up. The women included had localized provoked vulvodynia, refractory to first line treatment and were treated with 100*I.E. botulinum toxin electromyography (EMG) guided in the musculus levator ani in the period from March 2012 to May 2015(1). The outcome measures were: Dyspareunia, Negative Interference in Quality of Life (NIQL) and cotton swab test all rated on the numerical rating scale (NRS) and active vitae sexualis. Follow-up was conducted at six months.RESULTS: The women experienced significant improvements on, dyspareunia, which decreased to 5.82 from 7.82 (p < 0.01), NIQL to 6.19 from 7.88 (p < 0.01) and the cotton swab test to 5.50 from 6.81 (p < 0.01). No significant effect on Active Vitae Sexualis was found (p = 0.25).CONCLUSION: Women injected with 100*I.E. botulinum toxin EMG guided, diagnosed with localized provoked vulvodynia refractory to conventional non invasive treatment, had a reduction in dyspareunia and improved quality of life. Injection of botulinum toxin had no significant effect on vitae sexualis. Randomized controlled trials are, however, much needed.

KW - Botulinum toxins

KW - Dyspareunia

KW - Female

KW - NRS

KW - Pelvic pain

KW - Sexuality

KW - Type A

KW - Vulvodynia

UR - http://www.scopus.com/inward/record.url?scp=85059622751&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2018.12.013

DO - 10.1016/j.ejogrb.2018.12.013

M3 - Journal article

C2 - 30639955

VL - 234

SP - 6

EP - 9

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

SN - 0301-2115

IS - March

ER -