Both Poly(ethylene glycol) and Poly(methyl ethylene phosphate) Guide Oriented Adsorption of Specific Proteins

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  • Christoph Bernhard, Max Planck Institute for Polymer Research
  • ,
  • Steven Joop Roeters
  • Kristin N. Bauer, Max Planck Institute for Polymer Research
  • ,
  • Tobias Weidner
  • Mischa Bonn, Max Planck Institute for Polymer Research
  • ,
  • Frederik R. Wurm, Max Planck Institute for Polymer Research
  • ,
  • Grazia Gonella, Max Planck Institute for Polymer Research

Developing new functional biomaterials requires the ability to simultaneously repel unwanted and guide wanted protein adsorption. Here, we systematically interrogate the factors determining the protein adsorption by comparing the behaviors of different polymeric surfaces-polyethylene glycol and a polyphosphoester- A nd five different natural proteins. Interestingly we observe that at densities comparable to those used in nanocarrier functionalization, the same proteins are either adsorbed (fibrinogen, human serum albumin and transferrin) or repelled (immunoglobulin G and lysozyme) by both polymers. However, when adsorption takes place, the specific surface dictates the amount and the orientation of each protein.

OriginalsprogEngelsk
TidsskriftLangmuir
Vol/bind35
Nummer43
Sider (fra-til)14092-14097
Antal sider5
ISSN0743-7463
DOI
StatusUdgivet - okt. 2019

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